Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 66.7 | uM | 7462.085 | 0.5701 | -0.5274 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 333 | uM | 7462.085 | 0.9081 | 0.5618 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7462.085 | 0.9448 | 0.7287 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7462.085 | 1.0173 | 1.0899 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7462.085 | 1.0068 | 1.0353 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0213 | uM | 7462.085 | 0.9913 | 0.9556 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7462.085 | 0.9884 | 0.9408 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7462.085 | 0.9902 | 0.9501 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7462.085 | 1.0162 | 1.0845 | 0.3896 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.000427 | uM | 10019.002 | 1.0221 | 1.1151 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.0000853 | uM | 10019.002 | 1.0437 | 1.2308 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.00213 | uM | 10019.002 | 1.0600 | 1.3210 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.0107 | uM | 10019.002 | 0.8975 | 0.5170 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.0032 | uM | 10019.002 | 1.0643 | 1.3452 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.016 | uM | 10019.002 | 0.9807 | 0.9028 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.00064 | uM | 10019.002 | 1.0018 | 1.0092 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.000128 | uM | 10019.002 | 1.0808 | 1.4393 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.0533 | uM | 10019.002 | 0.9387 | 0.7015 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 33.3 | uM | 10019.002 | 0.7859 | 0.0807 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 6.67 | uM | 10019.002 | 0.7765 | 0.0482 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 0.267 | uM | 10019.002 | 0.8838 | 0.4586 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 1.33 | uM | 10019.002 | 0.9317 | 0.6692 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.08 | uM | 10019.002 | 0.8572 | 0.3492 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 0.4 | uM | 10019.002 | 0.8558 | 0.3434 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 2 | uM | 10019.002 | 0.9058 | 0.5532 | 0.3915 |