Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9158.037 | 1.0566 | 1.2484 | 0.4702 | |
| HCC1954 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 33.3 | uM | 7839.016 | 0.5827 | 0.4133 | 1.5556 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9158.037 | 1.0177 | 1.0761 | 0.4702 | |
| HCC202 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7840.016 | 0.9401 | 0.7638 | 0.4918 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9158.037 | 1.0599 | 1.2632 | 0.4702 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 11938.158 | 0.8619 | 0.5512 | 0.5846 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9158.037 | 0.5383 | -0.4642 | 0.4702 | |
| HCC202 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7840.016 | 0.7161 | 0.0142 | 0.4918 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7538.05 | 0.9765 | 0.9167 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7538.05 | 0.8365 | 0.4530 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7538.05 | 0.7857 | 0.2988 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7538.05 | 0.5289 | -0.3605 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7538.05 | 0.3569 | -0.6837 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7538.05 | 0.3663 | -0.6686 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7538.05 | 0.3192 | -0.7410 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7538.05 | 0.1224 | -0.9534 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7538.05 | 0.1918 | -0.8959 | 0.5587 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9158.037 | 0.9747 | 0.8937 | 0.4702 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9163.037 | 1.0245 | 1.0943 | 0.5258 | |
| HCC202 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7841.016 | 0.9452 | 0.7640 | 0.4493 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9163.037 | 1.0374 | 1.1445 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 11938.158 | 0.4363 | -0.5161 | 0.5846 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9163.037 | 1.0122 | 1.0466 | 0.5258 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 7508.074 | 0.8009 | 0.5112 | 0.7924 | |
| MDA-MB-361 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 7508.074 | 0.8009 | 0.5112 | 0.7924 |