Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HMT-3522 S1 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.00107 | uM | 10124.012 | 0.4850 | 0.3817 | 1.9565 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 0.213 | uM | 12220.135 | 0.8824 | 0.6530 | 0.6564 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.00107 | uM | 10147.012 | 0.5836 | 0.4442 | 1.6544 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 1.07 | uM | 12220.135 | 0.9250 | 0.7762 | 0.6564 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.000213 | uM | 10147.012 | 1.0001 | 1.0001 | 1.6544 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 5.33 | uM | 12220.135 | 0.8746 | 0.6308 | 0.6564 | |
| HMT-3522 S1 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.133 | uM | 10124.012 | 0.3995 | 0.2513 | 1.9565 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 26.7 | uM | 12220.135 | 0.8291 | 0.5033 | 0.6564 | |
| HMT-3522 S1 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.667 | uM | 10124.012 | 0.4440 | 0.3207 | 1.9565 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 133 | uM | 12220.135 | 0.7426 | 0.2711 | 0.6564 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.0000427 | uM | 10147.012 | 0.8672 | 0.8350 | 1.6544 | |
| HMT-3522 S1 | Unknown | Unknown | Taxol | TUBB | TUBB | 6.67 | uM | 10124.002 | 0.2924 | 0.1072 | 2.0795 | |
| HMT-3522 S1 | Unknown | Unknown | Trametinib | MEK | MAPK | 3.33 | uM | 10124.012 | 0.4021 | 0.2555 | 1.9565 | |
| HMT-3522 S1 | Unknown | Unknown | Taxol | TUBB | TUBB | 33.3 | uM | 10124.002 | 0.2768 | 0.0784 | 2.0795 | |
| HMT-3522 S1 | Unknown | Unknown | Trametinib | MEK | MAPK | 16.7 | uM | 10124.012 | 0.3986 | 0.2498 | 1.9565 | |
| HBL-100 | Unknown | Unknown | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7429.067 | 0.0056 | -0.8075 | 2.2169 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.667 | uM | 10147.012 | 0.4327 | 0.2054 | 1.6544 | |
| MB 157 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 1.33 | uM | 7482.069 | 0.7357 | 0.7367 | 2.1744 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.0267 | uM | 10147.012 | 0.4376 | 0.2136 | 1.6544 | |
| HMT-3522 T4-2 | Unknown | Unknown | Taxol | TUBB | TUBB | 6.67 | uM | 10147.002 | 0.1214 | -0.3166 | 1.9641 | |
| HMT-3522 S1 | Unknown | Unknown | Topotecan | TOP1 | TOP | 109 | uM | 7911.007 | 0.2669 | -0.1449 | 1.5549 | |
| MB 157 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 0.0107 | uM | 7482.069 | 0.9411 | 0.9450 | 2.1744 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 0.133 | uM | 10147.012 | 0.3502 | 0.0606 | 1.6544 | |
| MB 157 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 33.3 | uM | 7482.069 | 0.7171 | 0.7163 | 2.1744 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 3.33 | uM | 10147.012 | 0.3147 | -0.0057 | 1.6544 |