Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7797.016 | 0.8259 | 0.3799 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7797.016 | 0.7740 | 0.2168 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7797.016 | 0.8135 | 0.3401 | 0.5155 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7821.016 | 0.9969 | 0.9801 | 0.3100 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7793.016 | 0.9621 | 0.9345 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7818.016 | 0.3402 | -0.3848 | 0.9146 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7793.016 | 0.9450 | 0.9049 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9278.132 | 0.9700 | 0.8466 | 0.3815 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7793.016 | 0.9778 | 0.9617 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9278.132 | 1.0168 | 1.0894 | 0.3815 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7793.016 | 0.9595 | 0.9300 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9278.132 | 1.0479 | 1.2609 | 0.3815 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7793.016 | 0.9996 | 0.9993 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7818.016 | 0.9381 | 0.8650 | 0.9146 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7793.016 | 0.9314 | 0.8813 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7818.016 | 0.9972 | 0.9939 | 0.9146 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7793.016 | 0.8176 | 0.6816 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7794.016 | 0.9024 | 0.8976 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7793.016 | 0.8354 | 0.7132 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7819.016 | 1.0624 | 1.2403 | 0.5331 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7793.016 | 0.0495 | -0.8497 | 1.1616 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7818.016 | 0.9195 | 0.8246 | 0.9146 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7794.016 | 1.0541 | 1.0547 | 1.9541 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7824.016 | 1.0006 | 1.0007 | 1.7164 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7824.016 | 0.9396 | 0.9287 | 1.7164 |