Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7793.011 | 0.1724 | -0.5689 | 1.1456 | |
| MDA-MB-361 | HER2amp | Luminal | Mebendazole | 0.107 | uM | 13558.174 | 0.8978 | 0.6553 | 0.5699 | |||
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10095.001 | 0.5324 | -0.0035 | 0.9049 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7793.012 | 1.0214 | 1.0388 | 1.1030 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7793.011 | 0.1340 | -0.6541 | 1.1456 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7449.098 | 0.9193 | 0.9119 | 1.8675 | |
| AU565 | HER2amp | Luminal | IKK16 | IKK | NFKB | 2.67 | uM | 5900.093 | 0.6098 | 0.6143 | 2.3084 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7793.012 | 1.0903 | 1.1632 | 1.1030 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7793.011 | 0.1596 | -0.5971 | 1.1456 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12001.166 | 0.9754 | 0.9123 | 0.5565 | |
| AU565 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.000853 | uM | 5900.093 | 1.0125 | 1.0108 | 2.3084 | |
| HCC1954 | HER2amp | Basal A | Triciribine | AKT | AKT | 1.33 | uM | 7456.074 | 0.7516 | 0.7294 | 1.9647 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 2.62 | uM | 9146.12 | 0.1667 | -0.5997 | 1.1135 | |
| SK-BR-3 | HER2amp | Luminal | Mebendazole | 66.7 | uM | 12999.174 | 0.2956 | -0.5382 | 0.8315 | |||
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10095.001 | 0.5305 | -0.0074 | 0.9049 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12178.143 | 0.9247 | 0.8047 | 0.7617 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.021 | uM | 9146.12 | 0.3086 | -0.3042 | 1.1135 | |
| SK-BR-3 | HER2amp | Luminal | Mebendazole | 13.3 | uM | 12999.174 | 0.3087 | -0.5134 | 0.8315 | |||
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10019.001 | 1.0022 | 1.0111 | 0.3968 | |
| AU565 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10880.143 | 0.2715 | -0.1112 | 1.6077 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7793.011 | 0.1116 | -0.7052 | 1.1456 | |
| SK-BR-3 | HER2amp | Luminal | Mebendazole | 0.00427 | uM | 12999.174 | 1.0162 | 1.0390 | 0.8315 | |||
| AU565 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.000171 | uM | 5900.093 | 1.0737 | 1.0625 | 2.3084 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7825.05 | 1.0277 | 1.0300 | 1.8354 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9163.024 | 1.0483 | 1.1784 | 0.5524 |