Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 9972.017 | 0.1893 | -0.5198 | 1.1666 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9972.121 | 0.7198 | 0.4847 | 1.1034 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.08 | uM | 9972.002 | 0.6207 | 0.2445 | 1.0054 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 13.3 | uM | 11939.164 | 0.4221 | 0.1841 | 1.6455 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7555.074 | 0.8158 | 0.7702 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7555.074 | 0.3360 | 0.0402 | 1.6682 | |
| ZR75B | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7555.074 | 0.2768 | -0.0739 | 1.6682 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 0.000171 | uM | 11939.164 | 1.0044 | 1.0054 | 1.6455 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 2 | uM | 9997.002 | 0.7322 | 0.4528 | 0.9751 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.4 | uM | 9972.002 | 0.5890 | 0.1814 | 1.0054 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.016 | uM | 9972.002 | 0.6584 | 0.3198 | 1.0054 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.00064 | uM | 9972.002 | 0.9944 | 0.9888 | 1.0054 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.000128 | uM | 9997.002 | 1.0596 | 1.1224 | 0.9751 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10 | uM | 9972.002 | 0.6176 | 0.2383 | 1.0054 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7555.084 | 1.0284 | 1.0331 | 1.7052 | |
| ZR75B | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 9972.017 | 0.8197 | 0.6866 | 1.1666 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7555.084 | 0.9544 | 0.9460 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7555.084 | 1.0249 | 1.0290 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7555.084 | 0.9161 | 0.8998 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7555.084 | 0.9082 | 0.8901 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7555.084 | 0.8147 | 0.7735 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7555.084 | 0.0437 | -0.6809 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7555.084 | 0.0103 | -0.8636 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7555.084 | 0.0080 | -0.8819 | 1.7052 | |
| ZR75B | HR+ | Luminal | Docetaxel | TUBB | TUBB | 0.0000256 | uM | 9997.002 | 0.9960 | 0.9918 | 0.9751 |