Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Perturbagen Concentration	Perturbagen Conc Unit	Biological Replicate ID	Relative Cell Count	Normalized Growth Rate Inhibition Value	Nominal Division Rate
184A1	NM	Basal	5-DFUR	TYMS	TYMS	1.6	uM	12509.143	1.0174	1.0259	1.3392
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		6.67	uM	9047.132	0.8373	0.5511	0.6985
184A1	NM	Basal	5-DFUR	TYMS	TYMS	200	uM	12509.143	0.6536	0.4559	1.3392
184A1	NM	Basal	5-DFUR	TYMS	TYMS	0.064	uM	12509.143	1.0070	1.0104	1.3392
184A1	NM	Basal	5-DFUR	TYMS	TYMS	5000	uM	12509.143	0.2735	-0.2404	1.3392
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		33.3	uM	9047.132	0.7816	0.4055	0.6985
184A1	NM	Basal	17-AAG	HSP90	HSP90	0.032	uM	9047.037	0.4452	-0.5704	0.5262
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		0.0533	uM	9047.132	0.9788	0.9394	0.6985
184A1	NM	Basal	5-DFUR	TYMS	TYMS	0.0128	uM	12509.143	1.0576	1.0853	1.3392
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		167	uM	9047.132	0.9698	0.9141	0.6985
184A1	NM	Basal	17-AAG	HSP90	HSP90	0.16	uM	9047.037	0.4280	-0.6013	0.5262
184A1	NM	Basal	17-AAG	HSP90	HSP90	4	uM	9047.037	0.4226	-0.6108	0.5262
184A1	NM	Basal	17-AAG	HSP90	HSP90	0.8	uM	9047.037	0.4311	-0.5959	0.5262
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		0.267	uM	9047.132	0.9995	0.9985	0.6985
184A1	NM	Basal	5-FU	TYMS	TYMS	30.7	uM	9047.017	0.9094	0.7871	0.8440
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		0.000427	uM	9047.132	1.0270	1.0778	0.6985
184A1	NM	Basal	17-AAG	HSP90	HSP90	0.000256	uM	9047.037	0.9096	0.6705	0.5262
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		0.00213	uM	9047.132	0.9693	0.9128	0.6985
184A1	NM	Basal	5-FU	TYMS	TYMS	19200	uM	9047.017	0.1196	-0.8384	0.8440
184A1	NM	Basal	Afatinib	EGFR/HER2	ErbB	0.000853	uM	12509.165	0.9788	0.9717	1.5022
184A1	NM	Basal	Afatinib	EGFR/HER2	ErbB	0.00427	uM	12509.165	0.9185	0.8899	1.5022
184A1	NM	Basal	(Z)-4-Hydroxytamoxifen	ESR1		1.33	uM	9047.132	0.9661	0.9036	0.6985
184A1	NM	Basal	17-AAG	HSP90	HSP90	0.00128	uM	9047.037	1.0758	1.2981	0.5262
184A1	NM	Basal	AG1024	IGF1R	RTK	0.0533	uM	5894.066	1.0550	1.0725	1.5027
184A1	NM	Basal	AG1024	IGF1R	RTK	0.0107	uM	5894.066	1.0745	1.0980	1.5027

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)