Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 5898.091 | 0.9358 | 0.7959 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 5898.091 | 0.9895 | 0.9660 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 5898.091 | 0.5355 | -0.2745 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5.33 | uM | 5898.091 | 0.5705 | -0.1959 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 5898.091 | 1.0111 | 1.0362 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 26.7 | uM | 5898.091 | 0.0149 | -0.9978 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 5899.07 | 0.6294 | 0.1852 | 0.8850 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 5898.091 | 0.9553 | 0.8570 | 0.6159 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.00213 | uM | 12224.072 | 0.8924 | 0.7869 | 1.0105 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 12224.072 | 0.9826 | 0.9656 | 1.0105 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.267 | uM | 12224.072 | 0.9638 | 0.9284 | 1.0105 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0533 | uM | 12224.072 | 0.8949 | 0.7918 | 1.0105 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 5898.091 | 1.0031 | 1.0100 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 5899.07 | 0.3140 | -0.4598 | 0.8850 | |
| 600MPE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7791.016 | 1.0572 | 1.1416 | 0.8138 | ||
| 600MPE | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 9120.021 | 1.0333 | 1.1037 | 0.6486 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.267 | uM | 5898.073 | 0.9962 | 0.9883 | 0.6501 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 1.33 | uM | 5898.073 | 0.9306 | 0.7904 | 0.6501 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0533 | uM | 5898.073 | 1.0129 | 1.0398 | 0.6501 | |
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 3.33 | uM | 13091.176 | 0.9876 | 0.9717 | 0.8746 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 6.67 | uM | 5898.073 | 1.0135 | 1.0416 | 0.6501 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 0.0107 | uM | 5898.073 | 0.9763 | 0.9276 | 0.6501 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 5898.086 | 0.3778 | -0.6155 | 0.5904 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 33.3 | uM | 5898.073 | 0.9603 | 0.8792 | 0.6501 | |
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 0.0267 | uM | 13091.176 | 0.9505 | 0.8872 | 0.8746 |