Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 9972.019 | 0.8810 | 0.7757 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 9972.019 | 0.9593 | 0.9235 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 9972.019 | 0.9143 | 0.8387 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 9972.019 | 0.9222 | 0.8536 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 9972.019 | 1.0685 | 1.1283 | 1.0654 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9972.037 | 1.0435 | 1.0805 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9972.037 | 1.0102 | 1.0189 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9972.037 | 0.9585 | 0.9229 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9972.037 | 0.6239 | 0.2916 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9972.037 | 0.4702 | -0.0063 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9972.037 | 0.4289 | -0.0874 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9972.037 | 0.4167 | -0.1115 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9972.037 | 0.3716 | -0.2010 | 1.0789 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9972.037 | 0.1178 | -0.7246 | 1.0789 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 9972.121 | 0.5054 | 0.0776 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9972.121 | 0.8315 | 0.6920 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9972.121 | 1.0127 | 1.0229 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9972.121 | 0.8168 | 0.6649 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 9972.121 | 0.8423 | 0.7120 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9972.121 | 0.0849 | -0.7860 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 9972.121 | 0.3965 | -0.1352 | 1.1034 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9972.121 | 1.0186 | 1.0337 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 9972.121 | 0.0583 | -0.8479 | 1.1034 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9972.121 | 1.0160 | 1.0291 | 1.1034 | |
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 9972.121 | 0.1743 | -0.5893 | 1.1034 |