Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9501.037 | 1.0658 | 1.1317 | 0.9998 | |
| MDA-MB-453 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9708.019 | 1.0907 | 1.1558 | 1.1580 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 9420.132 | 1.0774 | 1.5055 | 0.3309 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7819.016 | 0.9523 | 0.8248 | 0.5331 | ||
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9501.037 | 1.0259 | 1.0518 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7860.04 | 0.0955 | -0.9301 | 0.7003 | |
| MDA-MB-453 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7903.016 | 0.0122 | -0.9610 | 1.1196 | ||
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7860.04 | 0.3418 | -0.5682 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7860.04 | 0.4013 | -0.4570 | 0.7003 | |
| MDA-MB-453 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7903.016 | 0.0252 | -0.9253 | 1.1196 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9420.132 | 1.0664 | 1.4288 | 0.3309 | ||
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7860.04 | 0.5922 | -0.0536 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7860.04 | 0.9522 | 0.8648 | 0.7003 | |
| MDA-MB-453 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7903.016 | 1.0389 | 1.0693 | 1.1196 | ||
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7860.04 | 1.0318 | 1.0914 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7860.04 | 1.0564 | 1.1630 | 0.7003 | |
| MDA-MB-453 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7903.016 | 1.0254 | 1.0453 | 1.1196 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 9420.132 | 1.1138 | 1.7703 | 0.3309 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7819.016 | 1.0010 | 1.0037 | 0.5331 | ||
| HBL-100 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7807.016 | 0.9478 | 0.9508 | 2.1516 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7797.016 | 0.8558 | 0.4785 | 0.5155 | ||
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7860.04 | 0.9738 | 0.9256 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7860.04 | 1.0467 | 1.1348 | 0.7003 | |
| MDA-MB-453 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7903.016 | 1.0149 | 1.0266 | 1.1196 | ||
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7857.05 | 0.0825 | -0.7270 | 1.2527 |