Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 11660.154 | 0.9379 | 0.8681 | 0.9388 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9278.001 | 0.9943 | 0.9745 | 0.4429 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 7457.066 | 0.8709 | 0.8402 | 1.6601 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7877.001 | 0.4812 | -0.6254 | 0.4366 | |
| MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 7878.016 | 0.9701 | 0.9575 | 1.4153 | |
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9047.001 | 0.7944 | 0.4834 | 0.7701 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12291.165 | 0.8517 | 0.5017 | 0.5602 | |
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10002.001 | 0.8276 | 0.4064 | 0.5372 | |
| 600MPE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 9118.019 | 0.8683 | 0.7529 | 1.0707 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9118.001 | 0.7710 | 0.5771 | 1.0946 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 7463.074 | 0.3167 | -0.8381 | 0.4574 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 9501.001 | 0.4643 | -0.0736 | 0.9969 | |
| HCC1187 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 6.67 | uM | 7812.016 | 0.9881 | 0.9775 | 1.0628 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9157.001 | 0.8892 | 0.7605 | 0.9211 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 7463.074 | 0.3167 | -0.8381 | 0.4574 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9163.001 | 0.8476 | 0.4575 | 0.5227 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9118.001 | 0.9113 | 0.8373 | 1.0946 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 6.67 | uM | 7911.001 | 0.0716 | -0.7777 | 1.2005 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 6.67 | uM | 7909.016 | 1.0559 | 1.0809 | 1.3701 | |
| HMT-3522 S1 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 6.67 | uM | 10124.001 | 0.2318 | 0.0248 | 2.1861 | |
| MDA-MB-157 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 7882.016 | 0.8919 | 0.8008 | 1.0905 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 10261.001 | 0.0825 | -0.3091 | 2.3472 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 6.67 | uM | 12428.165 | 0.9137 | 0.7596 | 0.7051 | |
| HCC1143 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 9233.001 | 0.4730 | -0.0656 | 0.9839 | |
| SUM159PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 9042.016 | 0.6283 | 0.6993 | 2.8524 |