Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 9997.121 | 1.1261 | 1.2254 | 1.1121 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9997.121 | 1.1243 | 1.2222 | 1.1121 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 33.3 | uM | 9997.049 | 0.8815 | 0.7909 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9997.049 | 0.9944 | 0.9901 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9997.049 | 1.0444 | 1.0775 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 100 | uM | 9997.049 | 1.0146 | 1.0255 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 500 | uM | 9997.049 | 0.9763 | 0.9585 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 20 | uM | 9997.049 | 1.0303 | 1.0530 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 6.67 | uM | 9997.049 | 0.9793 | 0.9637 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9997.049 | 1.0223 | 1.0390 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9997.049 | 0.6911 | 0.4474 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9997.049 | 0.9049 | 0.8325 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9997.049 | 0.7360 | 0.5292 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.8 | uM | 9997.049 | 0.9922 | 0.9863 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 9997.049 | 0.9429 | 0.8997 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0064 | uM | 9997.049 | 0.9700 | 0.9474 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9997.049 | 1.0152 | 1.0266 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9997.049 | 0.6815 | 0.4297 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.16 | uM | 9997.049 | 0.9476 | 0.9080 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9997.049 | 1.0084 | 1.0146 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.032 | uM | 9997.049 | 1.0231 | 1.0404 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9997.049 | 0.5498 | 0.1847 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9997.049 | 0.9879 | 0.9787 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00128 | uM | 9997.049 | 1.0060 | 1.0106 | 1.1423 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9997.049 | 1.0004 | 1.0006 | 1.1423 |