Highly-multiplexed imaging by Cyclic Immunofluorescence (CycIF) of protein levels and protein phosphorylation states in the MCF 10A breast cell line treated with EGF or four kinase inhibitors - Dataset (ID:20267)

Proteins Studied

LINCS ID Name HMS LINCS ID UniProt ID Alternative Names Provider Mutation Phosphlorylation State Domain Protein Description
200537 mTOR 200537 P42345
Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1
201349 NF-kB p65 201349 Q04206
Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
200598 VEGFR-2 200598 P35968
Vascular endothelial growth factor receptor 2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD309; VEGFR2
201335 Rb (pS807) 201335 P06400 pS807
201336 Rb (pS811) 201336 P06400 pS811
201337 ERK-1 (pT202) 201337 P27361 pT202
201338 ERK-2 (pT185) 201338 P28482 pT185
201339 Aurora kinase A (pT288) 201339 O14965 pT288
201304 ERK-2 (pT185; pY187) 201304 P28482 pT185; pY187
201341 Aurora kinase C (pT198) 201341 Q9UQB9 pT198
201298 S6 (pS235; pS236) 201298 P62753 pS235; pS236
201343 PARP-1 (D214-cleaved) 201343 P09874 D214-cleaved
201297 Rb (pS807; pS811) 201297 P06400 pS807; pS811
201294 H3 (pS10) 201294 P68431 pS10
201340 Aurora kinase B (pT232) 201340 Q96GD4 pT232
201303 ERK-1 (pT202; pY204) 201303 P27361 pT202; pY204
201314 H2A.X (pS139) 201314 P16104 pS139
201299 S6 (pS240; pS244) 201299 P62753 pS240; pS244
201348 Vimentin 201348 P08670