High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 270 229 image if available 650 7025 1251.1 283.87 11.58 3.56 859 957 1050 1150 1249 1356 1450 1553 1640 0.0757 532 1.003 35.47 12.37 1 0.1554 101 0.0018 76.01 6.355 0.1286 1650000.0
2260000000
3210000000000
4.71E+15
0.3546 0.2714 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0030 0.0000 0.0861 0.0357 0.1632 0.0683 0.0950 0.0233 0.1424 0.0714 0.5104 0.8012 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0020 0.0000 0.0405 0.0356 0.0729 0.0681 0.0304 0.0232 0.0547 0.0464 0.7996 0.8266 0.0000 1.0000 0.0000 0.0000 0.0000 0.0000 0.0127 0.0000 0.0828 0.0000 0.1083 0.0000 0.0573 0.0000 0.1083 0.0000 0.6306 0.0000 0.0000 0.0000 0.0000 0.0093 0.0556 0.0710 0.0525 0.0556 0.7562 7 9 10 11 11 12 13 14 16 0.0081 16.06 5.190 0.2777 146.9
2017.49
29808.4
471003
0.4942 0.1529 0.0108 0.0007 0.0396 0.0047 0.0930 0.0132 0.1508 0.0346 0.2124 0.0636 0.2362 0.1307 0.1635 0.2187 0.0792 0.3144 0.0144 0.2194 0.0046 0.0002 0.0197 0.0029 0.0427 0.0088 0.0534 0.0212 0.0813 0.0412 0.1242 0.0726 0.1697 0.1078 0.2247 0.2453 0.2797 0.5001 0.1226 0.2147 0.1534 0.1587 0.1534 0.1635 0.1480 0.1346 0.1180 0.1010 0.0987 0.0737 0.0887 0.0561 0.0717 0.0657 0.0455 0.0321 0.0277 0.0639 0.0858 0.1141 0.1354 0.1515 0.1521 0.1263 0.1433
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1060 312 image if available 8531 15239 406.2 51.13 226.15 245.25 342 364 380 392 404 416 431 449 474 0.0668 1018 0.868 57.87 17.89 1 0.0178 152 0.0013 38.37 6.954 0.1978 167626.0
70200000
29900000000
12900000000000
0.4561 0.1965 0.0000 0.0000 0.0001 0.0000 0.0013 0.0000 0.0042 0.0000 0.0191 0.0097 0.0469 0.0162 0.0566 0.0088 0.0892 0.0171 0.7825 0.9482 0.0000 0.0000 0.0000 0.0000 0.0001 0.0000 0.0011 0.0000 0.0126 0.0097 0.0255 0.0162 0.0268 0.0088 0.0439 0.0152 0.8900 0.9501 0.0146 1.0000 0.0419 0.0000 0.0419 0.0000 0.1129 0.0000 0.1548 0.0000 0.1876 0.0000 0.1220 0.0000 0.1275 0.0000 0.1967 0.0000 0.0026 0.0043 0.0115 0.0412 0.0740 0.1178 0.1135 0.1283 0.5068 15 19 31 68 137 220 311 421 569 0.0214 62.72 6.209 0.3748 111286.0
74000000
60400000000
58100000000000
0.5099 0.1391 0.0526 0.0022 0.1940 0.0114 0.2544 0.1134 0.1674 0.1438 0.1298 0.1878 0.1032 0.1837 0.0545 0.1188 0.0292 0.1096 0.0149 0.1292 0.0000 0.0001 0.0001 0.0004 0.0007 0.0003 0.0079 0.0047 0.0500 0.0399 0.0844 0.0694 0.0697 0.0522 0.1028 0.0844 0.6841 0.7486 0.0000 0.0004 0.0002 0.0009 0.0027 0.0049 0.0148 0.0281 0.0769 0.0926 0.1317 0.1530 0.1039 0.1070 0.1377 0.1459 0.5322 0.4672 0.0000 0.0000 0.0020 0.0090 0.0602 0.1073 0.0860 0.1254 0.6102
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 684 361 image if available 399 6206 58.4 9.74 24.73 66.86 46 49 52 54 57 61 64 69 72 0.1017 631 0.682 36.24 8.54 1 0.2607 104 0.0248 2.23 3.908 0.5277 3503.6
215851
13600000
881000000
0.3536 0.2676 0.0000 0.0000 0.0035 0.0000 0.0071 0.0000 0.0426 0.0101 0.0922 0.0628 0.1525 0.0678 0.1489 0.0653 0.1915 0.0879 0.3617 0.7060 0.0000 0.0000 0.0000 0.0000 0.0028 0.0000 0.0225 0.0100 0.0535 0.0627 0.0817 0.0677 0.0789 0.0652 0.1042 0.0677 0.6563 0.7268 0.0137 1.0000 0.0000 0.0000 0.0274 0.0000 0.0822 0.0000 0.0822 0.0000 0.1781 0.0000 0.1370 0.0000 0.2055 0.0000 0.2740 0.0000 0.0053 0.0053 0.0159 0.0265 0.0635 0.1111 0.1058 0.0899 0.5767 5 6 7 8 9 10 13 18 40 0.3348 9.79 2.064 0.7707 5081.6
2730000
1940000000
1570000000000
0.6341 0.0846 0.0349 0.0330 0.1163 0.0366 0.1453 0.0425 0.1628 0.0837 0.2006 0.1262 0.1919 0.1498 0.1163 0.1462 0.0233 0.1686 0.0087 0.2134 0.0053 0.0181 0.0079 0.0194 0.0184 0.0148 0.0202 0.0258 0.0746 0.0523 0.0886 0.0690 0.0912 0.0800 0.1202 0.1052 0.5737 0.6155 0.0025 0.0028 0.0013 0.0000 0.0088 0.0043 0.0251 0.0256 0.0842 0.0954 0.1256 0.1439 0.0942 0.1068 0.1344 0.1296 0.5239 0.4915 0.0022 0.0098 0.0065 0.0271 0.0869 0.0912 0.0988 0.1325 0.5451
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 828 731 image if available 4916 17078 344.5 49.98 70.06 109.17 278 302 316 330 344 358 374 391 410 0.0440 752 0.700 121.80 29.61 2 0.0728 358 0.0032 8.09 6.021 0.3596 121208.0
43500000
15900000000
5900000000000
0.4249 0.2173 0.0002 0.0000 0.0015 0.0000 0.0045 0.0000 0.0067 0.0000 0.0270 0.0128 0.0399 0.0214 0.0394 0.0128 0.0789 0.0218 0.8018 0.9312 0.0000 0.0000 0.0000 0.0000 0.0011 0.0000 0.0027 0.0000 0.0144 0.0128 0.0229 0.0214 0.0200 0.0128 0.0328 0.0185 0.9062 0.9345 0.0187 1.0000 0.0258 0.0000 0.0328 0.0000 0.0562 0.0000 0.1007 0.0000 0.1499 0.0000 0.1288 0.0000 0.1241 0.0000 0.3630 0.0000 0.0021 0.0041 0.0062 0.0144 0.0299 0.0533 0.0545 0.0685 0.7671 6 8 10 11 14 26 60 123 221 0.1196 5.30 3.437 0.5812 16825.5
6090000
2810000000
1590000000000
0.3847 0.2364 0.0327 0.0062 0.1401 0.0166 0.2424 0.0916 0.2139 0.1211 0.1718 0.1868 0.1149 0.2002 0.0516 0.1454 0.0263 0.1174 0.0063 0.1148 0.0000 0.0005 0.0006 0.0010 0.0023 0.0019 0.0083 0.0103 0.0391 0.0317 0.0712 0.0567 0.0463 0.0437 0.0805 0.0695 0.7518 0.7849 0.0000 0.0000 0.0009 0.0013 0.0021 0.0033 0.0145 0.0170 0.0532 0.0625 0.0907 0.0938 0.0628 0.0780 0.0937 0.1001 0.6822 0.6441 0.0004 0.0002 0.0032 0.0122 0.0464 0.0780 0.0622 0.0900 0.7075
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 740 703 image if available 8862 18824 530.1 80.43 114.15 251.56 421 467 496 517 535 553 573 598 631 0.0548 1032 0.545 114.22 22.67 5 0.0372 330 0.0009 38.41 7.314 0.2073 287452.0
159000000
89500000000
51200000000000
0.4491 0.2025 0.0001 0.0000 0.0006 0.0000 0.0007 0.0001 0.0056 0.0007 0.0282 0.0139 0.0564 0.0200 0.0512 0.0144 0.0715 0.0211 0.7858 0.9298 0.0000 0.0000 0.0000 0.0000 0.0000 0.0001 0.0016 0.0007 0.0179 0.0139 0.0306 0.0200 0.0252 0.0144 0.0335 0.0202 0.8913 0.9307 0.0075 1.0000 0.0188 0.0000 0.0225 0.0000 0.0476 0.0000 0.1164 0.0000 0.1640 0.0000 0.1014 0.0000 0.1502 0.0000 0.3717 0.0000 0.0006 0.0036 0.0074 0.0181 0.0434 0.0613 0.0734 0.0863 0.7059 9 10 12 13 15 20 38 121 352 0.1429 9.00 3.049 0.5952 76308.2
79500000
99600000000
139000000000000
0.5235 0.1294 0.0259 0.0023 0.0761 0.0164 0.2120 0.0561 0.1942 0.0865 0.2006 0.1645 0.1003 0.2050 0.1036 0.1458 0.0631 0.1341 0.0243 0.1894 0.0000 0.0004 0.0002 0.0004 0.0012 0.0011 0.0067 0.0072 0.0396 0.0383 0.0538 0.0475 0.0401 0.0385 0.0569 0.0591 0.8015 0.8073 0.0003 0.0000 0.0006 0.0006 0.0017 0.0021 0.0056 0.0079 0.0476 0.0539 0.0673 0.0667 0.0437 0.0521 0.0707 0.0758 0.7625 0.7409 0.0000 0.0005 0.0016 0.0065 0.0428 0.0586 0.0418 0.0664 0.7819
MDA-MB-231 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 1140 501 image if available 2795 5688 534.4 104.94 43.08 68.58 388 442 474 506 538 572 599 634 676 0.0939 534 0.836 78.23 21.02 2 0.0733 205 0.0014 24.71 6.757 0.2480 296615.0
170000000
100000000000
60500000000000
0.4327 0.2031 0.0000 0.0000 0.0022 0.0004 0.0017 0.0000 0.0094 0.0007 0.0409 0.0211 0.0819 0.0324 0.0658 0.0200 0.0946 0.0328 0.7035 0.8926 0.0000 0.0000 0.0000 0.0004 0.0004 0.0000 0.0039 0.0007 0.0215 0.0211 0.0369 0.0324 0.0292 0.0200 0.0442 0.0298 0.8638 0.8956 0.0019 1.0000 0.0058 0.0000 0.0154 0.0000 0.0288 0.0000 0.0538 0.0000 0.1019 0.0000 0.0596 0.0000 0.0904 0.0000 0.6423 0.0000 0.0021 0.0014 0.0035 0.0174 0.0306 0.0542 0.0480 0.0618 0.7811 3 4 6 7 9 16 32 74 139 0.1144 4.30 3.672 0.6245 6558.9
1480000
411000000
131000000000
0.3466 0.2662 0.0039 0.0100 0.0656 0.0116 0.1467 0.0282 0.2625 0.0664 0.2625 0.1678 0.1931 0.1860 0.0618 0.1794 0.0039 0.1910 0.0000 0.1595 0.0006 0.0026 0.0012 0.0037 0.0000 0.0053 0.0078 0.0100 0.0246 0.0238 0.0414 0.0365 0.0402 0.0396 0.0618 0.0497 0.8224 0.8288 0.0000 0.0000 0.0007 0.0015 0.0007 0.0008 0.0092 0.0124 0.0348 0.0372 0.0540 0.0581 0.0511 0.0550 0.0724 0.0790 0.7770 0.7560 0.0000 0.0000 0.0026 0.0059 0.0315 0.0538 0.0446 0.0649 0.7967
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 561 247 image if available 4445 15033 466.1 65.09 63.62 138.06 379 413 433 450 466 481 499 521 551 0.0559 840 1.186 46.40 17.49 1 0.0270 120 0.0015 34.76 6.820 0.2169 221513.0
107000000
52800000000
26400000000000
0.4116 0.2311 0.0000 0.0000 0.0000 0.0000 0.0011 0.0000 0.0035 0.0002 0.0355 0.0137 0.0646 0.0248 0.0635 0.0142 0.0910 0.0205 0.7407 0.9266 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0020 0.0002 0.0221 0.0137 0.0368 0.0248 0.0314 0.0142 0.0456 0.0187 0.8620 0.9284 0.0110 1.0000 0.0192 0.0000 0.0219 0.0000 0.0959 0.0000 0.1479 0.0000 0.1726 0.0000 0.1397 0.0000 0.1288 0.0000 0.2630 0.0000 0.0004 0.0036 0.0085 0.0278 0.0732 0.0996 0.0961 0.1302 0.5606 7 8 9 10 12 15 22 57 200 0.2619 11.61 3.053 0.7574 23105.5
14100000
11000000000
10100000000000
0.4691 0.1844 0.0363 0.0081 0.0726 0.0208 0.0726 0.0728 0.1501 0.0786 0.1622 0.1110 0.1671 0.1260 0.1574 0.1191 0.1090 0.1445 0.0726 0.3191 0.0003 0.0012 0.0013 0.0030 0.0023 0.0044 0.0077 0.0094 0.0229 0.0195 0.0265 0.0301 0.0245 0.0248 0.0368 0.0387 0.8777 0.8689 0.0011 0.0000 0.0011 0.0004 0.0022 0.0024 0.0108 0.0091 0.0238 0.0234 0.0309 0.0313 0.0313 0.0317 0.0395 0.0527 0.8593 0.8490 0.0003 0.0007 0.0048 0.0104 0.0214 0.0308 0.0235 0.0443 0.8637
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 838 827 image if available 348 3785 69.6 9.59 7.19 2.56 58 61 63 66 69 71 74 78 83 0.1007 381 1.208 26.48 9.85 4 0.2011 70 0.0757 0.82 2.819 0.6940 4931.9
356260
26200000
1970000000
0.3634 0.2597 0.0033 0.0000 0.0100 0.0000 0.0133 0.0029 0.0332 0.0144 0.0698 0.0720 0.0997 0.0778 0.1096 0.0692 0.2359 0.1268 0.4252 0.6369 0.0030 0.0000 0.0000 0.0000 0.0090 0.0029 0.0181 0.0144 0.0633 0.0690 0.0843 0.0776 0.0663 0.0690 0.1506 0.1149 0.6054 0.6523 0.0323 1.0000 0.0000 0.0000 0.1613 0.0000 0.2258 0.0000 0.1613 0.0000 0.0968 0.0000 0.1935 0.0000 0.1290 0.0000 0.0000 0.0000 0.0123 0.0062 0.0247 0.0988 0.1358 0.1420 0.1235 0.1728 0.2840 4 5 5 6 7 8 8 9 10 0.0188 7.92 4.396 0.3583 58.2
526.12
5258.33
57582.2
0.4841 0.1761 0.0222 0.0039 0.0672 0.0054 0.1627 0.0219 0.2267 0.0409 0.2391 0.0828 0.1725 0.1441 0.0826 0.2539 0.0246 0.3015 0.0025 0.1456 0.0046 0.0003 0.0185 0.0006 0.0490 0.0059 0.0817 0.0178 0.1214 0.0422 0.1762 0.0716 0.1689 0.1446 0.1823 0.2904 0.1974 0.4267 0.1226 0.1623 0.1493 0.1451 0.1143 0.1019 0.1184 0.1036 0.0917 0.0829 0.0937 0.0760 0.0814 0.0864 0.0937 0.1330 0.1349 0.1088 0.0153 0.0463 0.0769 0.1084 0.1441 0.1724 0.1585 0.1298 0.1483
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 305 753 image if available 14531 31502 446.4 61.03 117.13 162.48 365 402 424 439 452 464 476 491 515 0.0488 1538 0.844 110.02 27.80 4 0.0189 274 0.0017 18.96 6.823 0.2707 202963.0
93800000
44000000000
21000000000000
0.4307 0.2135 0.0003 0.0001 0.0001 0.0000 0.0009 0.0000 0.0036 0.0001 0.0149 0.0077 0.0284 0.0166 0.0253 0.0080 0.0383 0.0128 0.8882 0.9547 0.0001 0.0001 0.0000 0.0000 0.0000 0.0000 0.0019 0.0001 0.0098 0.0077 0.0186 0.0166 0.0149 0.0080 0.0188 0.0117 0.9360 0.9558 0.0148 1.0000 0.0239 0.0000 0.0091 0.0000 0.0262 0.0000 0.0809 0.0000 0.0945 0.0000 0.0809 0.0000 0.1173 0.0000 0.5524 0.0000 0.0022 0.0070 0.0123 0.0187 0.0346 0.0523 0.0642 0.0921 0.7167 13 16 21 33 52 79 118 180 305 0.0400 19.55 4.937 0.5597 40119.5
22800000
16800000000
14600000000000
0.4801 0.1897 0.0180 0.0019 0.0684 0.0102 0.1417 0.0304 0.1389 0.0605 0.1660 0.1385 0.1648 0.1775 0.1107 0.1263 0.1041 0.1394 0.0873 0.3154 0.0012 0.0003 0.0022 0.0020 0.0034 0.0030 0.0115 0.0124 0.0463 0.0387 0.0745 0.0614 0.0495 0.0472 0.0766 0.0656 0.7348 0.7694 0.0005 0.0007 0.0024 0.0020 0.0066 0.0068 0.0187 0.0217 0.0585 0.0622 0.0953 0.1084 0.0633 0.0699 0.0954 0.0979 0.6595 0.6304 0.0004 0.0017 0.0044 0.0151 0.0498 0.0888 0.0599 0.0831 0.6968
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 889 579 image if available 5344 14258 479.3 73.36 59.66 126.81 384 417 439 460 479 496 514 540 582 0.0560 799 1.214 72.84 31.83 1 0.0378 202 0.0020 11.27 6.511 0.3208 235079.0
118000000
60300000000
31500000000000
0.4020 0.2453 0.0002 0.0000 0.0005 0.0000 0.0014 0.0000 0.0066 0.0002 0.0216 0.0122 0.0337 0.0213 0.0309 0.0112 0.0475 0.0182 0.8575 0.9369 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0021 0.0002 0.0127 0.0122 0.0206 0.0213 0.0145 0.0112 0.0247 0.0167 0.9252 0.9384 0.0000 1.0000 0.0232 0.0000 0.0066 0.0000 0.0381 0.0000 0.0381 0.0000 0.0614 0.0000 0.0779 0.0000 0.0962 0.0000 0.6584 0.0000 0.0019 0.0026 0.0071 0.0160 0.0360 0.0527 0.0605 0.0854 0.7379 6 7 8 9 11 14 23 58 184 0.1961 6.16 3.029 0.6633 19637.6
11000000
8130000000
7350000000000
0.5394 0.1197 0.0721 0.0088 0.1081 0.0431 0.2450 0.1186 0.1766 0.0958 0.1315 0.1511 0.1045 0.1722 0.0829 0.1178 0.0541 0.1283 0.0252 0.1643 0.0010 0.0000 0.0013 0.0011 0.0048 0.0056 0.0166 0.0189 0.0507 0.0498 0.0842 0.0715 0.0555 0.0540 0.0778 0.0791 0.7083 0.7200 0.0008 0.0004 0.0027 0.0029 0.0023 0.0037 0.0139 0.0166 0.0616 0.0605 0.0953 0.0957 0.0581 0.0609 0.0817 0.0787 0.6836 0.6807 0.0007 0.0021 0.0021 0.0220 0.0535 0.0839 0.0676 0.0740 0.6941
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 372 900 image if available 5044 9324 570.5 98.09 110.30 193.81 423 504 548 574 591 608 625 644 675 0.0741 691 0.949 144.16 41.87 3 0.0765 386 0.0009 58.08 7.313 0.1858 335121.0
201000000
123000000000
76200000000000
0.4530 0.1918 0.0003 0.0000 0.0008 0.0000 0.0015 0.0002 0.0055 0.0012 0.0271 0.0139 0.0472 0.0212 0.0462 0.0133 0.0650 0.0234 0.8066 0.9268 0.0000 0.0000 0.0000 0.0000 0.0002 0.0002 0.0018 0.0012 0.0148 0.0139 0.0237 0.0212 0.0189 0.0133 0.0283 0.0218 0.9121 0.9285 0.0051 1.0000 0.0204 0.0000 0.0382 0.0000 0.0789 0.0000 0.1399 0.0000 0.1527 0.0000 0.1425 0.0000 0.1552 0.0000 0.2672 0.0000 0.0006 0.0016 0.0039 0.0132 0.0319 0.0631 0.0673 0.0879 0.7304 13 15 17 20 24 37 65 143 347 0.2499 4.68 3.068 0.7533 49725.0
35000000
30000000000
29200000000000
0.6863 0.0611 0.0201 0.0070 0.0828 0.0120 0.2081 0.0468 0.1834 0.0807 0.1969 0.1723 0.1454 0.1912 0.0805 0.1524 0.0403 0.1404 0.0425 0.1972 0.0004 0.0022 0.0004 0.0022 0.0021 0.0065 0.0116 0.0151 0.0418 0.0391 0.0708 0.0613 0.0472 0.0459 0.0911 0.0911 0.7345 0.7368 0.0000 0.0006 0.0005 0.0006 0.0051 0.0011 0.0142 0.0146 0.0524 0.0611 0.0956 0.0952 0.0478 0.0538 0.0935 0.0947 0.6909 0.6784 0.0000 0.0000 0.0019 0.0116 0.0551 0.0811 0.0487 0.0982 0.7034
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 655 519 image if available 12431 24620 390.0 70.08 73.02 145.52 287 322 350 376 398 418 437 454 476 0.0531 1307 0.717 116.71 35.11 3 0.0323 401 0.0014 13.24 6.814 0.3028 157023.0
65000000
27500000000
11900000000000
0.4378 0.1981 0.0007 0.0000 0.0029 0.0000 0.0055 0.0000 0.0115 0.0009 0.0276 0.0098 0.0447 0.0175 0.0492 0.0111 0.0732 0.0171 0.7847 0.9436 0.0001 0.0000 0.0009 0.0000 0.0019 0.0000 0.0037 0.0009 0.0122 0.0098 0.0195 0.0175 0.0178 0.0105 0.0271 0.0152 0.9168 0.9461 0.0102 1.0000 0.0215 0.0000 0.0269 0.0000 0.0449 0.0000 0.0682 0.0000 0.0922 0.0000 0.0999 0.0000 0.1191 0.0000 0.5171 0.0000 0.0007 0.0036 0.0042 0.0104 0.0227 0.0348 0.0407 0.0547 0.8282 8 10 11 13 15 20 33 82 218 0.1379 2.58 2.741 0.6004 26508.4
16200000
12600000000
11400000000000
0.6289 0.0769 0.0413 0.0027 0.1013 0.0182 0.1888 0.0633 0.1750 0.0919 0.1721 0.1461 0.1327 0.1875 0.1013 0.1379 0.0560 0.1347 0.0315 0.2176 0.0002 0.0005 0.0007 0.0006 0.0016 0.0015 0.0123 0.0101 0.0446 0.0428 0.0768 0.0683 0.0519 0.0466 0.0718 0.0703 0.7402 0.7592 0.0004 0.0009 0.0008 0.0018 0.0023 0.0018 0.0159 0.0140 0.0529 0.0605 0.0898 0.0918 0.0567 0.0628 0.0814 0.0868 0.6997 0.6794 0.0004 0.0000 0.0015 0.0114 0.0529 0.0806 0.0550 0.0825 0.7157
MCF 10A A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 613 713 image if available 713 1229 91.3 14.01 6.39 2.54 72 77 83 87 92 96 100 104 109 0.2522 310 1.070 24.52 7.28 1 0.0884 63 0.0680 0.69 2.897 0.7227 8522.9
813628
79300000
7870000000
0.3848 0.2534 0.0000 0.0000 0.0053 0.0000 0.0123 0.0014 0.0247 0.0014 0.0670 0.0492 0.0917 0.0646 0.1217 0.0478 0.1711 0.0772 0.5062 0.7584 0.0000 0.0000 0.0048 0.0000 0.0095 0.0014 0.0127 0.0014 0.0523 0.0491 0.0507 0.0645 0.0555 0.0477 0.0777 0.0659 0.7369 0.7700 0.0156 1.0000 0.0938 0.0000 0.0625 0.0000 0.1406 0.0000 0.2344 0.0000 0.1875 0.0000 0.0781 0.0000 0.1094 0.0000 0.0781 0.0000 0.0053 0.0107 0.0213 0.0373 0.0613 0.0587 0.0827 0.1280 0.5947 3 5 5 6 6 7 7 8 9 0.0448 0.26 0.778 0.2347 47.3
411.762
4361.59
56996.9
0.5177 0.1432 0.0094 0.0021 0.0336 0.0064 0.0983 0.0364 0.1023 0.0621 0.1911 0.1424 0.2248 0.1681 0.1736 0.2141 0.1279 0.2473 0.0390 0.1210 0.0000 0.0000 0.0048 0.0009 0.0183 0.0109 0.0502 0.0263 0.1187 0.1069 0.1525 0.1295 0.2008 0.1639 0.2346 0.2473 0.2201 0.3143 0.1365 0.2588 0.2048 0.1882 0.1468 0.1353 0.1433 0.1353 0.1502 0.0588 0.0785 0.0471 0.0512 0.0529 0.0375 0.0412 0.0512 0.0824 0.0038 0.0368 0.0722 0.1293 0.1812 0.1787 0.1496 0.1546 0.0938
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 400 407 image if available 6276 11399 375.7 86.02 140.41 164.45 245 323 357 378 396 413 428 444 463 0.0798 910 1.138 23.43 8.49 5 0.0099 62 0.0020 19.90 6.638 0.2782 148520.0
60600000
25300000000
10700000000000
0.3938 0.2401 0.0005 0.0000 0.0014 0.0000 0.0021 0.0000 0.0137 0.0000 0.0354 0.0108 0.0722 0.0252 0.0748 0.0104 0.1107 0.0183 0.6891 0.9352 0.0000 0.0000 0.0002 0.0000 0.0000 0.0000 0.0011 0.0000 0.0137 0.0108 0.0298 0.0252 0.0216 0.0104 0.0319 0.0169 0.9017 0.9367 0.0072 1.0000 0.0184 0.0000 0.0419 0.0000 0.0593 0.0000 0.0992 0.0000 0.1329 0.0000 0.1299 0.0000 0.1227 0.0000 0.3885 0.0000 0.0000 0.0010 0.0031 0.0067 0.0347 0.0601 0.0515 0.0772 0.7656 9 11 15 29 67 119 185 272 389 0.0593 7.25 4.451 0.5348 46754.1
20300000
10200000000
5650000000000
0.4511 0.1880 0.0237 0.0010 0.1225 0.0110 0.2381 0.0628 0.1729 0.1187 0.1275 0.1830 0.1265 0.1945 0.0810 0.1237 0.0632 0.1062 0.0445 0.1990 0.0000 0.0000 0.0008 0.0002 0.0017 0.0009 0.0089 0.0072 0.0450 0.0402 0.0820 0.0693 0.0542 0.0504 0.0858 0.0775 0.7214 0.7543 0.0003 0.0003 0.0030 0.0015 0.0041 0.0034 0.0160 0.0153 0.0574 0.0644 0.0907 0.1103 0.0655 0.0754 0.1045 0.1051 0.6586 0.6243 0.0002 0.0002 0.0019 0.0112 0.0594 0.0827 0.0622 0.0946 0.6875