PCI-32765 KiNativ -- single dose experiment - Dataset (ID:20206)
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| Small Molecule | Cell Line | Protein | Sequence | Labeling Site | % Inhibition | Assay compound conc | Conc unit |
|---|---|---|---|---|---|---|---|
| Ibrutinib | Ramos (RA 1) | RSK2 domain1 | DLKPENILLDEEGHIKLTDFGLSKESIDHEK | Lys2 | -17.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | RSK2_domain2 | DLKPSNILYVDESGNPESIR | Lys2 | 14.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SGK3 | FYAVKVLQK | Lys1 | 5.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SLK | DLKAGNILFTLDGDIK | Lys2 | -4.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | STLK5 | YSVKVLPWLSPEVLQQNLQGYDAK | Activation Loop | -14.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | STLK6 | SIKASHILISGDGLVTLSGLSHLHSLVK | Lys2 | 16.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SYK | TVAVKILK | Lys1 | 12.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SYK | ISDFGLSKALR | Activation Loop | 3.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TAO1,TAOK3 | DIKAGNILLTEPGQVK | Lys2 | -15.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TAOK2 | DVKAGNILLSEPGLVK | Lys2 | -19.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TEC | YVLDDQYTSSSGAKFPVK | Activation Loop | >90 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TLK1 | YLNEIKPPIIHYDLKPGNILLVDGTACGEIK | Lys2 | -41.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TLK1/2 | YLNEIKPPIIHYDLKPGNILLVNGTACGEIK | Lys2 | -2.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ULK3 | EVVAIKCVAK | Lys1 | -3.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ZAP70 | ISDFGLSKALGADDSYYTAR | Activation Loop | 10.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ZC1/HGK,ZC2/TNIK,ZC3/MINK | DIKGQNVLLTENAEVK | Lys2 | -45.9 | 1 | uM |