Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small Molecule Cell Line Drug Concentration Conc Units Timepoint Timepoint Units Measured pERK (Alexa 488) Measured p-Rb (Alexa 568) Alexa Fluor 647 Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) Image
Dactolisib T47D
100.0
nM
 6
hr
 75.87 27.61
p-4EBP1
 41.17 image if available
Dactolisib T47D
31.6
nM
 6
hr
 78.85 35.77
p-4EBP1
 95.11 image if available
Dactolisib T47D
100.0
nM
 6
hr
 80.72 30.01
p-S6
 3.74 image if available
Dactolisib T47D
100.0
nM
 6
hr
 84.56 34.41
p-Akt
 6.52 image if available
Dactolisib T47D
31.6
nM
 6
hr
 84.81 35.55
p-Akt
 8.51 image if available
Dactolisib T47D
3.16
uM
 6
hr
 84.83 32.58
p-4EBP1
 4.80 image if available
Dactolisib T47D
10.0
uM
 6
hr
 85.23 24.35
p-4EBP1
 5.42 image if available
Dactolisib T47D
10.0
uM
 6
hr
 85.91 37.58
p-S6
 3.98 image if available
Dactolisib T47D
3.16
uM
 6
hr
 86.04 36.41
p-Akt
 6.31 image if available
Dactolisib T47D
316.0
nM
 6
hr
 86.15 33.76
p-4EBP1
 14.31 image if available
MK2206 T47D
0 (control)
 6
hr
 87.33 30.74
p-4EBP1
 69.19 image if available
Dactolisib T47D
1.0
uM
 6
hr
 88.25 32.38
p-4EBP1
 5.74 image if available
Dactolisib T47D
0 (control)
 6
hr
 88.35 28.53
p-4EBP1
 84.26 image if available
MK2206 T47D
1.0
nM
 6
hr
 88.69 32.40
p-4EBP1
 70.25 image if available
Dactolisib T47D
31.6
nM
 6
hr
 88.70 45.24
p-Akt
 10.08 image if available
Dactolisib T47D
3.16
nM
 6
hr
 88.78 28.61
p-S6
 40.04 image if available
Dactolisib T47D
10.0
uM
 6
hr
 88.85 36.94
p-S6
 4.07 image if available
Dactolisib T47D
1.0
uM
 6
hr
 88.97 38.37
p-4EBP1
 6.28 image if available
Dactolisib T47D
316.0
nM
 6
hr
 88.99 42.86
p-Akt
 6.47 image if available
Dactolisib T47D
10.0
nM
 6
hr
 89.53 39.74
p-4EBP1
 114.99 image if available
Dactolisib T47D
0 (control)
 6
hr
 89.64 29.16
p-S6
 44.67 image if available
Dactolisib T47D
1.0
uM
 6
hr
 89.72 38.09
p-S6
 3.89 image if available
Dactolisib T47D
10.0
uM
 6
hr
 90.13 33.66
p-4EBP1
 5.00 image if available
Dactolisib T47D
31.6
nM
 6
hr
 90.16 29.57
p-S6
 4.68 image if available
Dactolisib T47D
100.0
nM
 6
hr
 90.18 40.47
p-S6
 4.14 image if available
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