Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 168.78 | 30.99 | p-4EBP1 | 42.45 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 182.86 | 43.74 | p-4EBP1 | 53.60 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 273.26 | 74.15 | p-4EBP1 | 88.08 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 288.02 | 127.19 | p-4EBP1 | 143.69 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 142.39 | 29.98 | p-4EBP1 | 49.89 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 315.68 | 118.54 | p-4EBP1 | 151.92 | | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 294.05 | 67.35 | p-4EBP1 | 84.02 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 447.87 | 123.71 | p-4EBP1 | 188.29 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 518.22 | 130.83 | p-4EBP1 | 239.81 | | |
| Gefitinib | HCC1954 | 0 (control) | 6 | hr | 352.31 | 73.66 | p-4EBP1 | 81.10 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 337.11 | 90.46 | p-4EBP1 | 107.99 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 329.11 | 121.18 | p-4EBP1 | 136.59 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 298.17 | 123.52 | p-4EBP1 | 156.31 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 217.78 | 65.35 | p-4EBP1 | 91.17 | | |
| Gefitinib | AU565 | 0 (control) | 6 | hr | 226.23 | 50.86 | p-4EBP1 | 51.79 | | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 597.19 | 141.39 | p-4EBP1 | 180.42 | | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 520.08 | 134.68 | p-4EBP1 | 226.94 | | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 234.34 | 56.31 | p-4EBP1 | 61.94 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 443.02 | 135.36 | p-4EBP1 | 212.85 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 277.93 | 72.56 | p-4EBP1 | 95.48 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 223.15 | 50.37 | p-4EBP1 | 55.92 | | |
| Dactolisib | AU565 | 0 (control) | 24 | hr | 527.81 | 136.32 | p-4EBP1 | 202.58 | | |
| Torkinib | HCC1954 | 0 (control) | 24 | hr | 299.58 | 124.61 | p-4EBP1 | 139.95 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 434.95 | 158.69 | p-4EBP1 | 306.67 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 323.44 | 115.77 | p-4EBP1 | 138.95 | |