Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 17-AAG | SUM1315MO2 | -4.0000 | 0.8799 | -6.6145 | -6.5024 | -7.8064 | 1.2761 | 0.1652 | 0.2197 | 5.5249 |
| 17-AAG | SUM185PE | -4.0000 | 0.8775 | -7.3695 | -7.2978 | -7.5310 | 3.1600 | 0.1923 | 0.1923 | 4.8675 |
| 17-AAG | SUM225CWN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | SUM52PE | -4.0000 | 0.8939 | -7.2410 | -6.9159 | -7.7059 | 0.8461 | 0.2178 | 0.2196 | 5.0957 |
| 17-AAG | 184A1 | -4.0000 | 0.8258 | -7.7910 | -7.5836 | -8.0006 | 2.4610 | 0.3454 | 0.3454 | 5.1026 |
| 17-AAG | MCF7 | -4.0000 | 0.8873 | -6.0400 | -5.5267 | -6.2554 | 0.6306 | 0.2628 | 0.2990 | 6.5267 |
| 17-AAG | SK-BR-3 | -4.0000 | 0.8661 | -7.1800 | -6.4291 | -7.4935 | 0.5343 | 0.2889 | 0.2896 | 5.6780 |
| 17-AAG | AU565 | -4.0000 | 0.8220 | -6.4130 | -6.2516 | -7.0894 | 0.6432 | 0.1231 | 0.2127 | 5.6376 |
| 17-AAG | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | BT-549 | -4.0000 | 0.9841 | -7.5275 | -7.5014 | -7.5490 | 3.9985 | 0.0952 | 0.0952 | 4.0970 |
| 17-AAG | CAMA-1 | -4.0000 | 0.9115 | -6.1150 | -5.5666 | -6.6202 | 0.5996 | 0.2504 | 0.2945 | 6.4789 |
| 17-AAG | HCC1395 | -4.0000 | 0.8972 | -5.9790 | -5.7146 | -6.7611 | 0.5356 | 0.1172 | 0.1989 | 6.3873 |
| 17-AAG | HCC1419 | -4.0000 | 0.9222 | -6.7240 | -6.4874 | -7.5167 | 0.9458 | 0.1718 | 0.1854 | 5.6387 |
| 17-AAG | HCC1937 | -4.0000 | 0.9736 | -6.9450 | -6.8969 | -6.9901 | 3.9990 | 0.1822 | 0.1822 | 5.2613 |
| 17-AAG | HCC1954 | -4.0000 | 0.9123 | -7.4570 | -7.2736 | -7.5312 | 2.1480 | 0.1899 | 0.1899 | 4.6514 |
| 17-AAG | HCC38 | -4.0000 | 0.9507 | -7.0200 | -6.8296 | -7.2836 | 1.4475 | 0.2327 | 0.2334 | 5.4493 |
| 17-AAG | HCC70 | -4.0000 | 0.9574 | -6.3990 | -6.2152 | -6.6518 | 1.4880 | 0.1835 | 0.1884 | 6.0999 |
| 17-AAG | MDA-MB-134-VI | -4.0000 | 0.9871 | -7.1850 | -7.1306 | -7.3874 | 2.5250 | 0.1285 | 0.1285 | 4.6601 |
| 17-AAG | MDA-MB-157 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | MDA-MB-361 | -4.0000 | 0.9853 | -7.1865 | -7.1428 | -7.2781 | 3.9990 | 0.1527 | 0.1527 | 4.8491 |
| 17-AAG | MDA-MB-436 | -4.0000 | 0.7863 | -5.1445 | -5.1444 | -6.2076 | 0.4534 | 0.0000 | 0.2328 | 6.7347 |
| 17-AAG | UACC-893 | -4.0000 | 0.8927 | -7.1970 | -7.1266 | -7.3685 | 2.6970 | 0.1775 | 0.1775 | 4.8815 |
| 17-AAG | ZR-75-1 | -4.0000 | 0.9417 | -6.8275 | -6.6116 | -6.8577 | 3.3130 | 0.3959 | 0.3959 | 6.4398 |
| 17-AAG | HCC2185 | -4.0000 | 0.9649 | -6.6605 | -6.4227 | -7.0748 | 1.6940 | 0.2975 | 0.2980 | 5.9764 |
| 17-AAG | 600MPE | -4.0000 | 0.8393 | -5.9890 | -5.7998 | -7.3145 | 0.8335 | 0.1732 | 0.3543 | 6.1967 |