Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Trametinib | MCF12A | -4.7773 | 0.9782 | -8.4908 | -8.1545 | -8.6879 | 1.1815 | 0.2996 | 0.2996 | 4.9284 |
| Ixabepilone | SUM149PT | -4.4045 | 0.9637 | -8.2275 | -8.1536 | -8.3009 | 1.3730 | 0.1035 | 0.1035 | 3.6488 |
| Torkinib | MDA-MB-134-VI | -4.3010 | 0.9644 | -8.3700 | -8.1441 | -9.5949 | 0.3310 | 0.0793 | 0.1189 | 3.4999 |
| Vinorelbine | HCC1954 | -4.3335 | 0.8463 | -8.2095 | -8.1427 | -8.3181 | 2.9650 | 0.1842 | 0.1842 | 3.8895 |
| Geldanamycin | SUM159PT | -4.0000 | 0.9944 | -8.1560 | -8.1410 | -8.1970 | 2.6035 | 0.0400 | 0.0400 | 2.8392 |
| Taxol | Hs 578T | -4.4776 | 0.9832 | -8.2421 | -8.1401 | -8.4267 | 1.4310 | 0.1391 | 0.1391 | 3.9251 |
| Vinorelbine | MDA-MB-468 | -4.3335 | 0.9074 | -8.1695 | -8.1270 | -8.2193 | 3.9980 | 0.1619 | 0.1619 | 3.9040 |
| Taxol | BT-549 | -4.4776 | 0.9814 | -8.1951 | -8.1066 | -8.1839 | 3.1955 | 0.2355 | 0.2355 | 4.5825 |
| Ixabepilone | SUM229PE | -4.4045 | 0.9201 | -8.2320 | -8.1023 | -8.6795 | 0.8597 | 0.1193 | 0.1255 | 3.9019 |
| Docetaxel | CAMA-1 | -5.0000 | 0.9704 | -8.2760 | -8.0939 | -8.3245 | 3.9980 | 0.4062 | 0.4062 | 5.9096 |
| Docetaxel | HCC1187 | -5.0000 | 0.9777 | -8.1190 | -8.0930 | -8.6425 | 1.4650 | 0.0712 | 0.0712 | 4.4403 |
| Taxol | MDA-MB-468 | -4.4776 | 0.9946 | -8.1086 | -8.0920 | -8.1719 | 3.9990 | 0.0721 | 0.0721 | 3.6461 |
| Vinorelbine | MDA-MB-231 | -4.3335 | 0.8987 | -8.3230 | -8.0849 | -8.3051 | 1.3138 | 0.1745 | 0.1745 | 3.8716 |
| Torkinib | AU565 | -4.3010 | 0.9687 | -8.5760 | -8.0828 | -8.9348 | 0.5460 | 0.2310 | 0.2346 | 4.0207 |
| Ixabepilone | LY2 | -4.4045 | 0.9574 | -8.1385 | -8.0814 | -8.2570 | 2.0620 | 0.1187 | 0.1187 | 3.9722 |
| Vinorelbine | BT-549 | -4.3335 | 0.9427 | -8.0965 | -8.0750 | -8.1222 | 3.2750 | 0.0776 | 0.0776 | 3.3764 |
| Geldanamycin | MCF 10F | -4.0000 | 0.9860 | -8.1020 | -8.0697 | -8.1444 | 2.7410 | 0.0931 | 0.0931 | 3.3677 |
| Taxol | HCC1806 | -4.4776 | 0.9897 | -8.0876 | -8.0685 | -8.1579 | 2.7400 | 0.0655 | 0.0655 | 3.6186 |
| GSK461364 | UACC-893 | -4.4776 | 0.7393 | -8.2951 | -8.0674 | -8.3748 | 3.9960 | 0.4309 | 0.4309 | 5.6830 |
| GSK461364 | SUM52PE | -4.4776 | 0.9315 | -8.2401 | -8.0625 | -8.2787 | 2.7230 | 0.3025 | 0.3025 | 4.8266 |
| Torkinib | HCC1954 | -4.3010 | 0.9756 | -8.3140 | -8.0526 | -8.9641 | 0.3341 | 0.0911 | 0.1308 | 3.6259 |
| Trametinib | MCF 10A | -4.7773 | 0.9761 | -8.2693 | -8.0487 | -8.2293 | 1.6805 | 0.2626 | 0.2626 | 4.9256 |
| Taxol | SUM149PT | -4.4776 | 0.9614 | -8.1036 | -8.0475 | -8.1202 | 4.0000 | 0.2002 | 0.2002 | 4.7283 |
| Vinorelbine | HCC1395 | -4.3335 | 0.9719 | -8.1050 | -8.0457 | -8.3061 | 2.4500 | 0.1351 | 0.1351 | 3.8075 |
| Ixabepilone | MDA-MB-134-VI | -4.4045 | 0.8225 | -8.3685 | -8.0317 | -8.6548 | 1.3050 | 0.3186 | 0.3186 | 4.7657 |