Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 5-FU | MDA-MB-436 | -1.7167 | 0.7179 | -2.7477 | -2.4610 | -3.3629 | 0.5233 | 0.1459 | 0.3373 | 7.2900 |
| Olomoucine II | MDA-MB-231 | -3.8761 | 0.7196 | -4.9011 | -4.8569 | -4.8980 | 3.9920 | 0.1675 | 0.1676 | 8.6571 |
| Baicalein | SUM159PT | -3.7773 | 0.7209 | -4.3232 | -4.3232 | -4.3449 | 3.9990 | 0.0000 | 0.0065 | 8.7764 |
| (Z)-4-Hydroxytamoxifen | HCC1428 | -3.7773 | 0.7209 | -4.2667 | -4.2667 | NaN | 0.3206 | 0.0000 | 0.4106 | 6.8703 |
| XRP44X | BT-474 | -3.8761 | 0.7217 | -5.4566 | -3.8761 | -5.6052 | 2.5750 | 0.5740 | 0.5824 | 8.0983 |
| AG1478 | T47D | -3.7773 | 0.7221 | -4.4695 | -4.1221 | -4.7567 | 0.6829 | 0.2105 | 0.4094 | 7.5112 |
| Vinorelbine | HCC1143 | -4.3335 | 0.7251 | -7.5695 | -7.3296 | -7.5171 | 3.9960 | 0.4451 | 0.4451 | 6.2724 |
| GSK1838705A | BT-20 | -4.1759 | 0.7254 | -5.3809 | -5.2943 | -5.4635 | 3.9970 | 0.2736 | 0.2736 | 7.8780 |
| Sunitinib | ZR75B | -3.7773 | 0.7264 | -5.1123 | -5.0614 | -5.1454 | 3.9930 | 0.1860 | 0.1860 | 6.8685 |
| CGC-11047 | HCC2185 | -2.3010 | 0.7274 | -2.8409 | -2.8409 | -4.3514 | 1.3850 | 0.0000 | 0.1625 | 6.8356 |
| Trametinib | ZR75B | -4.7773 | 0.7284 | -7.6263 | -4.7773 | -4.7773 | 0.5066 | 0.8157 | 0.8221 | 8.3485 |
| GSK461364 | 184B5 | -4.4776 | 0.7303 | -5.5881 | -5.5882 | -6.3658 | 0.4307 | 0.0000 | 0.2496 | 6.7499 |
| GSK923295 | SUM185PE | -4.4776 | 0.7315 | -4.9198 | -4.9198 | -5.4984 | 1.6835 | 0.0000 | 0.1662 | 7.6372 |
| CPT-11 | UACC-812 | -4.0696 | 0.7320 | -4.9925 | -4.0696 | -5.1365 | 1.8045 | 0.5239 | 0.5421 | 8.6213 |
| CGC-11047 | Hs 578T | -2.3010 | 0.7333 | -3.5660 | -3.5658 | NaN | 0.3139 | 0.0000 | 0.2862 | 6.0454 |
| Nutlin 3a | MDA-MB-175-VII | -4.1759 | 0.7346 | -4.4642 | -4.2380 | -5.3052 | 0.7904 | 0.0000 | 0.4824 | 7.7723 |
| Vinorelbine | T47D | -4.3335 | 0.7351 | -4.9618 | -4.9619 | -5.7842 | 1.6100 | 0.0000 | 0.0887 | 6.8027 |
| GSK923295 | UACC-893 | -4.4776 | 0.7353 | -7.4576 | -5.6887 | -7.5478 | 3.2150 | 0.4906 | 0.4906 | 6.6240 |
| Everolimus | HCC1143 | -4.1759 | 0.7354 | -5.4069 | -5.4069 | NaN | 0.3199 | 0.0000 | 0.2877 | 6.1721 |
| XRP44X | HCC1569 | -3.8761 | 0.7363 | -5.7191 | -3.8761 | -5.3606 | 1.1140 | 0.5651 | 0.5689 | 8.1058 |
| Tozasertib | LY2 | -4.0000 | 0.7365 | -5.0460 | -5.0458 | -6.0259 | 0.4839 | 0.0000 | 0.2377 | 6.2912 |
| Gefitinib | HCC1187 | -4.4776 | 0.7375 | -4.3209 | -4.4776 | -4.5207 | 2.1830 | 0.0069 | 0.6893 | 8.9050 |
| Nutlin 3a | T47D | -4.1759 | 0.7382 | -4.0549 | -4.2805 | -4.5633 | 0.9696 | 0.0000 | 0.4870 | 7.8995 |
| Erlotinib | BT-549 | -4.1759 | 0.7384 | -4.1790 | -4.1791 | -4.2949 | 0.7034 | 0.0000 | 0.4987 | 8.4973 |
| Nutlin 3a | T47DKBLUC | -4.1759 | 0.7386 | -4.1099 | -4.2340 | -4.4720 | 1.1655 | 0.0000 | 0.5297 | 8.4073 |