Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Docetaxel | MDA-MB-436 | -5.0000 | 0.8183 | -7.7540 | -7.4465 | -7.7477 | 3.9940 | 0.4703 | 0.4703 | 6.9177 |
| Gefitinib | Hs 578T | -4.4776 | 0.8184 | -4.7687 | -4.7686 | -4.8241 | 2.3305 | 0.0001 | 0.2335 | 8.3697 |
| Ixabepilone | SUM185PE | -4.4045 | 0.8184 | -6.3905 | -6.3904 | NaN | 0.3353 | 0.0000 | 0.1775 | 5.2632 |
| AG1478 | MDA-MB-361 | -3.7773 | 0.8186 | -4.5263 | -3.9210 | -4.8228 | 1.0250 | 0.1829 | 0.4632 | 7.9758 |
| Torkinib | SUM185PE | -4.3010 | 0.8186 | -5.8140 | -4.9089 | -5.9164 | 1.3930 | 0.4726 | 0.4767 | 7.6185 |
| Temsirolimus | HCC38 | -3.8761 | 0.8186 | -5.6571 | -5.6573 | NaN | 0.2527 | 0.0000 | 0.2618 | 5.3829 |
| 5-DFUR | MCF7 | -2.3010 | 0.8187 | -3.6250 | -2.3010 | -3.8407 | 1.0180 | 0.5231 | 0.5436 | 7.6867 |
| 5-DFUR | MX1 | -2.3010 | 0.8188 | -2.3676 | -2.3675 | -2.9598 | 1.0810 | 0.0000 | 0.4587 | 7.4046 |
| AG1478 | HCC1569 | -3.7773 | 0.8190 | -5.0463 | -4.6358 | -5.3792 | 0.7269 | 0.1016 | 0.3161 | 6.6668 |
| Sigma A6730 | UACC-812 | -4.1759 | 0.8191 | -4.9801 | -4.6862 | -5.5461 | 0.7077 | 0.0878 | 0.3422 | 7.3315 |
| Oxamflatin | MDA-MB-231 | -4.1759 | 0.8193 | -5.5509 | -5.5427 | -5.5779 | 3.9930 | 0.0364 | 0.0364 | 7.6753 |
| Everolimus | HCC70 | -4.1759 | 0.8194 | -5.7659 | -5.7658 | NaN | 0.3055 | 0.0000 | 0.2464 | 5.7929 |
| Tozasertib | UACC-812 | -4.0000 | 0.8195 | -4.5034 | -4.5034 | -4.9544 | 1.8730 | 0.0000 | 0.1024 | 7.1924 |
| Baicalein | HCC1937 | -3.7773 | 0.8195 | -4.4964 | -3.7773 | -4.4328 | 3.9700 | 0.5194 | 0.5201 | 8.6281 |
| Olomoucine II | HCC1419 | -3.8761 | 0.8205 | -4.8563 | -4.5755 | -5.4150 | 0.9757 | 0.2339 | 0.3102 | 7.3462 |
| CGC-11047 | HCC202 | -2.3010 | 0.8206 | -3.2353 | -3.2354 | -5.2705 | 0.9265 | 0.0000 | 0.1452 | 6.5999 |
| Gefitinib | MCF7 | -4.4776 | 0.8208 | -4.4459 | -4.4776 | -4.5825 | 1.0390 | 0.0000 | 0.5190 | 8.1555 |
| CGC-11047 | BT-483 | -2.3010 | 0.8210 | -2.7831 | -2.4601 | -3.2758 | 1.5504 | 0.2775 | 0.4450 | 8.1875 |
| Erlotinib | HCC1187 | -4.1759 | 0.8211 | -4.4427 | -4.1759 | -5.0264 | 2.1787 | 0.3236 | 0.5934 | 8.1299 |
| Temsirolimus | SUM159PT | -3.8761 | 0.8214 | -6.5161 | -6.5159 | -6.6252 | 0.3483 | 0.0000 | 0.1075 | 4.7580 |
| Epirubicin | BT-483 | -3.7645 | 0.8216 | -5.0465 | -5.0469 | -6.7952 | 0.4296 | 0.0000 | 0.2195 | 6.3459 |
| GSK923295 | MCF 10F | -4.4776 | 0.8219 | -6.1677 | -4.7707 | -6.3486 | 1.1462 | 0.2546 | 0.4445 | 6.9424 |
| Carboplatin | MDA-MB-468 | -2.8697 | 0.8220 | -4.1407 | -4.1411 | -4.2978 | 2.2170 | 0.0000 | 0.0028 | 6.7013 |
| 17-AAG | AU565 | -4.0000 | 0.8220 | -6.4130 | -6.2516 | -7.0894 | 0.6432 | 0.1231 | 0.2127 | 5.6376 |
| Ixabepilone | MDA-MB-134-VI | -4.4045 | 0.8225 | -8.3685 | -8.0317 | -8.6548 | 1.3050 | 0.3186 | 0.3186 | 4.7657 |