Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Lestaurtinib | ZR-75-1 | -4.4776 | 0.8071 | -4.9951 | -4.9951 | -5.8634 | 0.5333 | 0.0000 | 0.3460 | 7.1442 |
| 5-DFUR | BT-20 | -2.3010 | 0.8072 | -2.8957 | -2.4068 | -3.5554 | 0.5198 | 0.2009 | 0.4854 | 7.5241 |
| 5-DFUR | UACC-893 | -2.3010 | 0.8073 | -2.0053 | -2.3010 | -4.0077 | 0.3772 | 0.0000 | 0.5639 | 7.7344 |
| Nutlin 3a | BT-474 | -4.1759 | 0.8073 | -4.6679 | -4.1759 | -4.7055 | 3.9870 | 0.5042 | 0.5096 | 8.6932 |
| Bosutinib | SUM225CWN | -4.0000 | 0.8073 | -5.2475 | -4.8760 | -5.9288 | 0.6629 | 0.1917 | 0.3358 | 6.7676 |
| GSK1838705A | HCC1937 | -4.1759 | 0.8073 | -5.2979 | -5.2364 | -5.3389 | 3.9960 | 0.2160 | 0.2160 | 8.1699 |
| Everolimus | SUM149PT | -4.1759 | 0.8074 | -5.2949 | -5.2951 | -5.4567 | 0.4086 | 0.0000 | 0.2586 | 6.3509 |
| Nutlin 3a | BT-549 | -4.1759 | 0.8078 | -4.6423 | -4.3786 | -4.4570 | 3.0725 | 0.3924 | 0.4259 | 8.4938 |
| Vinorelbine | HCC2185 | -4.3335 | 0.8082 | -4.7912 | -4.7912 | -5.4939 | 2.6260 | 0.0000 | 0.0591 | 6.4923 |
| GSK1070916 | ZR75B | -4.4776 | 0.8084 | -4.6326 | -4.6513 | -5.7720 | 0.3741 | 0.0000 | 0.4696 | 7.4366 |
| CGC-11047 | ZR75B | -2.3010 | 0.8085 | -2.9384 | -2.9384 | -3.5582 | 1.0595 | 0.0000 | 0.2371 | 7.1828 |
| MG-132 | SUM159PT | -4.1759 | 0.8087 | -7.3579 | -7.3438 | -7.3854 | 3.6760 | 0.0556 | 0.0556 | 4.2496 |
| Temsirolimus | MDA-MB-134-VI | -3.8761 | 0.8091 | -5.1301 | -5.1297 | NaN | 0.3561 | 0.0000 | 0.2635 | 5.9702 |
| GSK1070916 | MCF12A | -4.4776 | 0.8094 | -5.0180 | -5.0180 | -5.2827 | 1.0610 | 0.0000 | 0.2108 | 7.3701 |
| Afatinib | MDA-MB-231 | -4.1759 | 0.8094 | -5.3729 | -5.3722 | -5.4047 | 3.9980 | 0.0030 | 0.0030 | 8.0481 |
| XRP44X | BT-20 | -3.8761 | 0.8096 | -5.4871 | -3.8761 | -5.3396 | 2.0185 | 0.5449 | 0.5451 | 7.5268 |
| 5-DFUR | SK-BR-3 | -2.3010 | 0.8096 | -2.5574 | -2.5574 | NaN | 0.2672 | 0.0000 | 0.4606 | 6.9216 |
| Erlotinib | HCC202 | -4.1759 | 0.8097 | -3.9822 | -4.1759 | -4.4598 | 1.4430 | 0.0005 | 0.6557 | 8.4795 |
| Everolimus | MCF12A | -4.1759 | 0.8100 | -4.9545 | -4.9545 | -5.1396 | 0.6839 | 0.0000 | 0.2269 | 6.8060 |
| 5-DFUR | BT-474 | -2.3010 | 0.8103 | -2.0940 | -2.3010 | -3.3351 | 0.3593 | 0.0000 | 0.5427 | 8.0229 |
| MG-132 | HCC202 | -4.1759 | 0.8103 | -6.4399 | -6.2507 | -6.8778 | 1.9790 | 0.2885 | 0.2885 | 6.1639 |
| Epirubicin | MDA-MB-157 | -3.7645 | 0.8114 | -6.3615 | -6.3350 | -6.4068 | 4.0000 | 0.1065 | 0.1065 | 5.1224 |
| GSK461364 | MDA-MB-436 | -4.4776 | 0.8119 | -7.8636 | -7.3063 | -7.8969 | 2.3230 | 0.3729 | 0.3729 | 6.0263 |
| Pevonedistat | BT-474 | -4.1759 | 0.8119 | -6.0089 | -4.1759 | -6.3137 | 0.7222 | 0.4512 | 0.5128 | 7.0802 |
| Everolimus | MDA-MB-231 | -4.1759 | 0.8122 | -4.3634 | -4.3634 | -4.2563 | 3.9980 | 0.0000 | 0.1511 | 8.1620 |