Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Docetaxel | HCC1954 | -5.0000 | 0.9115 | -8.6430 | -8.5724 | -8.8092 | 1.2620 | 0.0624 | 0.0624 | 3.8091 |
| Docetaxel | SUM149PT | -5.0000 | 0.9360 | -8.8090 | -8.6657 | -8.8072 | 2.3100 | 0.2665 | 0.2665 | 4.7876 |
| Docetaxel | SUM52PE | -5.0000 | 0.9765 | -8.6740 | -8.4669 | -8.7954 | 1.5570 | 0.2588 | 0.2588 | 4.8421 |
| Omipalisib | 184A1 | -4.4776 | 0.9136 | -8.6666 | -8.1611 | -8.7804 | 0.9289 | 0.3302 | 0.3303 | 4.7168 |
| Omipalisib | SUM225CWN | -4.4776 | 0.9049 | -8.0816 | -7.7460 | -8.7709 | 0.5508 | 0.1734 | 0.1819 | 4.3953 |
| Omipalisib | HCC1419 | -4.4776 | 0.9393 | -7.8176 | -7.3177 | -8.7550 | 0.7216 | 0.2822 | 0.2850 | 5.2439 |
| Torkinib | HCC1143 | -4.3010 | 0.9605 | -7.8290 | -7.4652 | -8.7515 | 0.3324 | 0.1215 | 0.1768 | 4.2921 |
| Omipalisib | MDA-MB-361 | -4.4776 | 0.9850 | -7.9296 | -7.9292 | -8.7448 | 0.8961 | 0.0000 | 0.0012 | 3.5825 |
| Docetaxel | HCC38 | -5.0000 | 0.9818 | -8.6120 | -8.4709 | -8.7384 | 1.9535 | 0.2238 | 0.2238 | 4.5902 |
| Gemcitabine | HCC1806 | -3.8416 | 0.9790 | -8.6516 | -8.5897 | -8.7366 | 2.1030 | 0.1252 | 0.1252 | 2.5814 |
| Ixabepilone | HCC1187 | -4.4045 | 0.9872 | -8.6105 | -8.6026 | -8.7327 | 3.2200 | 0.0327 | 0.0327 | 2.8018 |
| Trametinib | 184A1 | -4.7773 | 0.9456 | -8.4983 | -6.0092 | -8.7160 | 1.0862 | 0.4990 | 0.4991 | 6.0545 |
| Ixabepilone | Hs 578T | -4.4045 | 0.9537 | -8.6775 | -8.6117 | -8.7153 | 1.3270 | 0.1267 | 0.1267 | 3.5228 |
| Docetaxel | MDA-MB-468 | -5.0000 | 0.9839 | -8.5860 | -8.5206 | -8.7081 | 1.8710 | 0.0837 | 0.0837 | 3.8228 |
| Torkinib | CAMA-1 | -4.3010 | 0.9747 | -7.5440 | -7.3453 | -8.7061 | 0.4644 | 0.0956 | 0.1229 | 4.4086 |
| Vinorelbine | Hs 578T | -4.3335 | 0.9828 | -8.4295 | -8.3827 | -8.6943 | 2.6070 | 0.0730 | 0.0730 | 3.0790 |
| Ixabepilone | HCC1954 | -4.4045 | 0.9770 | -8.5815 | -8.5657 | -8.6882 | 1.6170 | 0.0543 | 0.0543 | 2.8292 |
| Trametinib | MCF12A | -4.7773 | 0.9782 | -8.4908 | -8.1545 | -8.6879 | 1.1815 | 0.2996 | 0.2996 | 4.9284 |
| Ixabepilone | SUM229PE | -4.4045 | 0.9201 | -8.2320 | -8.1023 | -8.6795 | 0.8597 | 0.1193 | 0.1255 | 3.9019 |
| Docetaxel | HCC1806 | -5.0000 | 0.9937 | -8.5945 | -8.5659 | -8.6584 | 2.1230 | 0.0853 | 0.0853 | 3.8338 |
| Omipalisib | MCF 10F | -4.4776 | 0.9586 | -8.2176 | -8.0168 | -8.6572 | 0.7082 | 0.1396 | 0.1415 | 4.0322 |
| Ixabepilone | MDA-MB-134-VI | -4.4045 | 0.8225 | -8.3685 | -8.0317 | -8.6548 | 1.3050 | 0.3186 | 0.3186 | 4.7657 |
| GSK461364 | HCC1954 | -4.4776 | 0.9031 | -8.6121 | -8.5601 | -8.6498 | 3.7270 | 0.1966 | 0.1966 | 3.8376 |
| Docetaxel | MCF 10A | -5.0000 | 0.9724 | -8.6485 | -8.4958 | -8.6453 | 1.4580 | 0.1865 | 0.1866 | 4.3758 |
| Docetaxel | HCC1187 | -5.0000 | 0.9777 | -8.1190 | -8.0930 | -8.6425 | 1.4650 | 0.0712 | 0.0712 | 4.4403 |