Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Taxol | SUM229PE | -4.4776 | 0.9844 | -7.7836 | -7.5710 | -7.7818 | 2.4190 | 0.3225 | 0.3225 | 5.5947 |
| GSK461364 | HCC3153 | -4.4776 | 0.9419 | -7.7731 | -6.0544 | -7.7749 | 3.9995 | 0.4331 | 0.4331 | 6.0629 |
| GSK461364 | Hs 578T | -4.4776 | 0.9074 | -7.7706 | -7.6340 | -7.8504 | 2.5630 | 0.2968 | 0.2968 | 5.2331 |
| Geldanamycin | BT-474 | -4.0000 | 0.9824 | -7.7705 | -7.6527 | -7.8856 | 3.5905 | 0.3031 | 0.3031 | 5.0989 |
| Docetaxel | HCC1419 | -5.0000 | 0.7471 | -7.7670 | -5.0000 | -7.8886 | 1.6530 | 0.7057 | 0.7057 | 8.4471 |
| Docetaxel | UACC-893 | -5.0000 | 0.8516 | -7.7670 | -7.4530 | -7.8897 | 3.9970 | 0.4722 | 0.4722 | 7.5379 |
| Omipalisib | HCC1187 | -4.4776 | 0.9588 | -7.7646 | -7.5385 | -8.2829 | 0.5880 | 0.0853 | 0.1112 | 4.4995 |
| Vinorelbine | MDA-MB-134-VI | -4.3335 | 0.7975 | -7.7635 | -7.5799 | -7.8968 | 3.1780 | 0.3601 | 0.3601 | 5.5120 |
| Geldanamycin | MDA-MB-361 | -4.0000 | 0.9906 | -7.7620 | -7.7279 | -7.9231 | 3.9970 | 0.1620 | 0.1620 | 4.1263 |
| Taxol | 184A1 | -4.4776 | 0.8586 | -7.7586 | -4.4776 | -7.1300 | 1.5600 | 0.6613 | 0.6613 | 7.5136 |
| Omipalisib | HCC1569 | -4.4776 | 0.9648 | -7.7576 | -7.5276 | -7.7975 | 1.2645 | 0.2412 | 0.2413 | 5.1165 |
| Taxol | UACC-893 | -4.4776 | 0.8644 | -7.7571 | -6.0194 | -7.8858 | 3.3115 | 0.5061 | 0.5061 | 7.1464 |
| Vinorelbine | HCC38 | -4.3335 | 0.9214 | -7.7570 | -7.6518 | -7.9162 | 2.5860 | 0.1921 | 0.1922 | 4.5617 |
| Gemcitabine | AU565 | -3.8416 | 0.9938 | -7.7556 | -7.6986 | -7.8877 | 2.5020 | 0.1406 | 0.1406 | 3.7074 |
| Ixabepilone | T47DKBLUC | -4.4045 | 0.7124 | -7.7555 | -7.0138 | -8.0200 | 0.7261 | 0.3552 | 0.3576 | 5.8298 |
| Docetaxel | MDA-MB-436 | -5.0000 | 0.8183 | -7.7540 | -7.4465 | -7.7477 | 3.9940 | 0.4703 | 0.4703 | 6.9177 |
| Taxol | HCC3153 | -4.4776 | 0.9571 | -7.7516 | -7.4172 | -7.7456 | 2.1960 | 0.4086 | 0.4086 | 5.9891 |
| GSK923295 | UACC-812 | -4.4776 | 0.8565 | -7.7516 | -4.4776 | -7.7834 | 3.9960 | 0.5864 | 0.5864 | 7.1470 |
| Topotecan | AU565 | -3.9626 | 0.9944 | -7.7496 | -7.7184 | -7.7936 | 2.4000 | 0.0780 | 0.0780 | 3.5241 |
| Ixabepilone | T47D | -4.4045 | 0.9194 | -7.7495 | -7.5412 | -7.8976 | 1.3420 | 0.2373 | 0.2373 | 5.1704 |
| Gemcitabine | MCF 10A | -3.8416 | 0.9637 | -7.7446 | -7.5227 | -7.7141 | 1.0420 | 0.2014 | 0.2014 | 4.2132 |
| Ispinesib | MDA-MB-468 | -4.4776 | 0.9803 | -7.7276 | -7.6985 | -7.7951 | 2.4010 | 0.0684 | 0.0684 | 4.1851 |
| GSK923295 | MDA-MB-468 | -4.4776 | 0.8812 | -7.7266 | -7.6512 | -7.8595 | 1.7550 | 0.1626 | 0.1626 | 4.6745 |
| Torkinib | HCC1428 | -4.3010 | 0.7953 | -7.7250 | -7.4406 | -9.2993 | 0.2643 | 0.0796 | 0.1814 | 4.2525 |
| Omipalisib | MCF7 | -4.4776 | 0.9876 | -7.7246 | -7.5630 | -8.1347 | 1.0240 | 0.1581 | 0.1585 | 4.6877 |