Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Imatinib | UACC-893 | -3.2480 | 0.9798 | -4.5520 | -4.5520 | -4.7819 | 2.5830 | 0.0000 | 0.0005 | 6.4846 |
| GSK1070916 | HCC1428 | -4.4776 | 0.9550 | -4.8857 | -4.8856 | -5.6712 | 1.5860 | 0.0000 | 0.1599 | 7.7067 |
| GSK1070916 | HCC1569 | -4.4776 | 0.9060 | -5.6529 | -5.6530 | -6.1004 | 0.5168 | 0.0000 | 0.2019 | 6.5482 |
| GSK1070916 | HCC1806 | -4.4776 | 0.9314 | -5.0186 | -5.0186 | -5.0488 | 2.4110 | 0.0000 | 0.0473 | 7.4139 |
| GSK1070916 | HCC1937 | -4.4776 | 0.8305 | -4.8158 | -4.8552 | -5.7750 | 0.4686 | 0.0000 | 0.3979 | 7.2970 |
| GSK1070916 | HCC1954 | -4.4776 | 0.9120 | -5.3490 | -5.3489 | -5.5470 | 1.2750 | 0.0000 | 0.0774 | 7.4421 |
| GSK1070916 | HCC202 | -4.4776 | 0.8263 | -4.8108 | -4.8108 | -5.8427 | 0.8376 | 0.0000 | 0.3447 | 7.6824 |
| GSK1070916 | HCC38 | -4.4776 | 0.9041 | -5.7636 | -5.7637 | -6.4859 | 0.5460 | 0.0000 | 0.1725 | 6.4217 |
| GSK1070916 | HCC70 | -4.4776 | 0.8789 | -5.6596 | -5.6592 | -6.4477 | 0.4719 | 0.0000 | 0.2000 | 6.6848 |
| GSK1070916 | Hs 578T | -4.4776 | 0.9154 | -5.9386 | -5.9390 | -6.4229 | 0.5351 | 0.0000 | 0.1410 | 6.1417 |
| Imatinib | MCF 10F | -3.2480 | 0.9698 | -4.5325 | -4.5326 | -4.7421 | 2.4455 | 0.0000 | 0.0059 | 6.8208 |
| GSK1070916 | MDA-MB-134-VI | -4.4776 | 0.8155 | -4.5868 | -4.5868 | -5.5744 | 0.5597 | 0.0000 | 0.4864 | 7.9183 |
| GSK1070916 | MDA-MB-157 | -4.4776 | 0.7855 | -5.6706 | -5.6709 | -5.9571 | 0.4644 | 0.0000 | 0.2182 | 6.4360 |
| Afatinib | HCC38 | -4.1759 | 0.9583 | -5.6009 | -5.6012 | -5.7817 | 1.3420 | 0.0000 | 0.0121 | 6.1539 |
| GSK1070916 | MDA-MB-361 | -4.4776 | 0.9615 | -5.0034 | -5.0034 | -5.2835 | 2.9475 | 0.0000 | 0.0308 | 7.7162 |
| Imatinib | SUM159PT | -3.2480 | 0.9729 | -4.9070 | -4.9068 | -4.9231 | 3.9930 | 0.0000 | 0.0000 | 6.3954 |
| GSK1070916 | MDA-MB-453 | -4.4776 | 0.8573 | -5.1036 | -5.1035 | -5.6475 | 1.3077 | 0.0000 | 0.1426 | 7.3238 |
| Tozasertib | HCC70 | -4.0000 | 0.7843 | -5.2470 | -5.2466 | NaN | 0.3821 | 0.0000 | 0.2503 | 6.3077 |
| GSK1070916 | T47D | -4.4776 | 0.9317 | -4.7860 | -4.7859 | -5.4249 | 1.3980 | 0.0000 | 0.2704 | 7.9162 |
| Imatinib | SUM225CWN | -3.2480 | 0.9795 | -4.6485 | -4.6481 | -4.8764 | 2.4335 | 0.0000 | 0.0006 | 6.5728 |
| MG-132 | HCC1187 | -4.1759 | 0.9800 | -6.9169 | -6.9165 | -7.1022 | 1.7230 | 0.0000 | 0.0000 | 4.3524 |
| GSK461364 | MCF 10F | -4.4776 | 0.8285 | -6.0156 | -6.0160 | -7.2051 | 0.4255 | 0.0000 | 0.2392 | 6.1498 |
| GSK1070916 | 184B5 | -4.4776 | 0.9613 | -5.3762 | -5.3761 | -6.1627 | 0.5692 | 0.0000 | 0.2357 | 7.0319 |
| Lestaurtinib | HCC1395 | -4.4776 | 0.9239 | -6.0661 | -6.0657 | -6.9291 | 0.5978 | 0.0000 | 0.1029 | 6.0443 |
| Lestaurtinib | HCC1143 | -4.4776 | 0.9191 | -6.1356 | -6.1354 | -6.5259 | 0.6055 | 0.0000 | 0.0902 | 5.8695 |