HMS LINCS Project
Library of Integrated Network-based Cellular Signatures
HMS LINCS Database
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BEZ235 KINOMEscan
- Dataset (ID:20096)
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Small Molecules Studied
Proteins Studied
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Small molecules
Proteins
10232:Dactolisib
200001:AAK1
200002:ABL1
200003:ABL1(E255K)
200005:ABL1(F317I)
200008:ABL1(F317L)
200011:ABL1(H396P)
200014:ABL1(M351T)
200016:ABL1(Q252H)
200019:ABL1(T315I)
200022:ABL1(Y253F)
200026:ABL2
200027:ACVR1
200028:ACVR1B
200029:ACVR2A
200030:ACVR2B
200031:ACVRL1
200032:ADCK3
200033:ADCK4
200034:AKT1
200035:AKT2
200036:AKT3
200037:ALK
200038:AMPK-alpha1
200039:AMPK-alpha2
200040:ANKK1
200041:NUAK1
200042:M3K5
200043:M3K6
200044:AURKA
200045:AURKB
200046:AURKC
200047:AXL
200048:BIKE
200049:BLK
200050:BMPR1A
200051:BMPR1B
200052:BMPR2
200053:BMX
200054:BRAF
200055:BRAF(V600E)
200056:PTK6
200057:BRSK1
200058:BRSK2
200059:BTK
200060:CAMK1
200061:CAMK1D
200062:CAMK1G
200063:CAMK2A
200064:CAMK2B
200065:KCC2D
200066:CAMK2G
200067:KCC4
200068:KKCC1
200069:CAMKK2
200071:CDC2L1
200072:CDC2L2
200074:CDK11
200075:CDK2
200076:CDK3
200079:CDK5
200080:CDK7
200081:CDK8
200082:CDK9
200084:CDKL2
200085:CDKL3
200086:CDKL5
200087:CHEK1
200088:CHK2
200089:CIT
200090:CLK1
200091:CLK2
200092:CLK3
200093:CLK4
200094:CSF1R
200095:CSK
200097:CSNK1A1L
200098:CSNK1D
200099:CSNK1E
200100:KC1G1
200101:KC1G2
200102:CSNK1G3
200103:CSNK2A1
200104:CSNK2A2
200105:CTK
200106:DAPK1
200107:DAPK2
200108:DAPK3
200109:DCLK1
200110:DCAMKL2
200111:DCAMKL3
200112:DDR1
200113:DDR2
200114:M3K12
200115:DMPK
200116:DMPK2
200117:DRAK1
200118:DRAK2
200119:DYRK1A
200120:DYRK1B
200121:DYRK2
200122:EGFR
200123:EGFR(E746-A750del)
200124:EGFR(G719C)
200125:EGFR(G719S)
200126:EGFR(L747-E749del, A750P)
200127:EGFR(L747-S752del, P753S)
200128:EGFR(L747-T751del,Sins)
200129:EGFR(L858R)
200130:EGFR(L858R,T790M)
200131:EGFR(L861Q)
200132:EGFR(S752-I759del)
200135:EPHA1
200136:EPHA2
200137:EPHA3
200138:EPHA4
200139:EPHA5
200140:EPHA6
200141:EPHA7
200142:EPHA8
200143:EPHB1
200144:EPHB2
200145:EPHB3
200146:EPHB4
200147:EPHB6
200148:ERBB2
200149:ERBB3
200150:ERBB4
200151:MK03
200152:MK01
200153:ERK3
200154:ERK4
200155:ERK5
200156:ERK8
200157:ERN1
200158:FAK1
200159:FER
200160:FES
200161:FGFR1
200162:FGFR2
200163:FGFR3
200164:FGFR3(G697C)
200165:FGFR4
200166:FGR
200167:VGFR1
200168:FLT3
200169:FLT3(D835H)
200170:FLT3(D835Y)
200171:FLT3(ITD)
200172:FLT3(K663Q)
200173:FLT3(N841I)
200175:FLT4
200176:FRK
200177:FYN
200178:GAK
200179:GCN2(Kin.Dom.2,S808G)
200180:GRK1
200181:GRK4
200182:GRK7
200183:GSK3A
200184:GSK3B
200185:HCK
200186:HIPK1
200187:HIPK2
200188:HIPK3
200189:HIPK4
200190:M4K1
200191:HUNK
200192:ICK
200193:IGF1R
200194:IKKA
200195:IKKB
200196:IKKE
200197:INSR
200198:INSRR
200199:IRAK1
200200:IRAK3
200202:ITK
200203:JAK1(JH1domain-catalytic)
200204:JAK1(JH2domain-pseudokinase)
200207:JAK2(JH1domain-catalytic)
200209:JAK3(JH1domain-catalytic)
200211:JNK1
200212:MK09
200213:JNK3
200214:KIT
200217:KIT(D816V)
200218:KIT(L576P)
200219:KIT(V559D)
200220:KIT(V559D,T670I)
200221:KIT(V559D,V654A)
200222:LATS1
200223:LATS2
200224:LCK
200225:LIMK1
200226:LIMK2
200227:LKB1
200228:LOK
200231:LTK
200232:LYN
200233:M3K13
200234:MAK
200235:MAP3K1
200236:MAP3K15
200237:M3K2
200238:MAP3K3
200239:MAP3K4
200240:MAP4K2
200241:M4K3
200242:MAP4K4
200243:MAP4K5
200244:MAPKAPK2
200245:MAPKAPK5
200246:MARK1
200247:MARK2
200248:MARK3
200249:MARK4
200250:MAST1
200251:MP2K1
200252:MP2K2
200253:MP2K3
200254:MP2K4
200256:MP2K6
200257:MELK
200258:MERTK
200259:MET
200260:MET(M1250T)
200261:MET(Y1235D)
200262:MINK
200264:MKNK1
200265:MKNK2
200266:MLCK
200267:MLK1
200268:MLK2
200269:MLK3
200270:MRCKA
200271:MRCKB
200272:MST1
200273:MST1R
200274:MST2
200275:MST3
200276:MST4
200278:MUSK
200279:MYLK
200280:MYLK2
200281:MYLK4
200282:MYO3A
200283:MYO3B
200284:NDR1
200285:NDR2
200286:NEK1
200288:NEK2
200291:NEK5
200292:NEK6
200293:NEK7
200294:NEK9
200295:NIM1
200296:NLK
200297:OSR1
200298:MK14
200299:MK11
200300:MK13
200301:MK12
200302:PAK1
200303:PAK2
200304:PAK3
200305:PAK4
200306:PAK6
200307:PAK7
200309:CDK16
200310:PCTK2
200311:PCTK3
200312:PGFRA
200313:PGFRB
200314:PDPK1
200317:CDK15
200318:CDK14
200319:PHKG1
200320:PHKG2
200321:PIK3C2B
200322:PIK3C2G
200323:PIK3CA
200324:PIK3CA(C420R)
200325:PIK3CA(E542K)
200326:PIK3CA(E545A)
200327:PIK3CA(E545K)
200328:PIK3CA(H1047L)
200329:PIK3CA(H1047Y)
200331:PIK3CA(M1043I)
200332:PIK3CA(Q546K)
200333:PIK3CB
200334:PIK3CD
200335:PIK3CG
200336:PIK4CB
200337:PIM1
200338:PIM2
200339:PIM3
200340:PIP5K1A
200342:PIP5K2B
200344:PKAC-alpha
200345:PKAC-beta
200346:PKMYT1
200347:PKN1
200348:PKN2
200350:PLK1
200351:PLK2
200352:PLK3
200353:PLK4
200354:KPCD
200355:KPCE
200356:KPCL
200358:KPCT
200359:KPCD1
200360:KPCD2
200361:KPCD3
200362:KGP1
200363:KGP2
200364:PRKR
200365:PRKX
200366:PRP4
200367:FAK2
200368:SIK3
200369:RAF1
200370:RET
200371:RET(M918T)
200372:RET(V804L)
200373:RET(V804M)
200374:RIOK1
200375:RIOK2
200376:RIOK3
200377:RIPK1
200378:RIPK2
200379:RIPK4
200381:ROCK1
200382:ROCK2
200383:ROS1
200384:RPS6KA1(Kin.Dom.1)
200385:RPS6KA1(Kin.Dom.2)
200386:RPS6KA2(Kin.Dom.1)
200387:RPS6KA2(Kin.Dom.2)
200388:RPS6KA3(Kin.Dom.1)
200390:RPS6KA4(Kin.Dom.1-N-terminal)
200392:RPS6KA4(Kin.Dom.2-C-terminal)
200394:RPS6KA5(Kin.Dom.1-N-terminal)
200396:RPS6KA5(Kin.Dom.2-C-terminal)
200397:RPS6KA6(Kin.Dom.1)
200398:RPS6KA6(Kin.Dom.2)
200407:SBK1
200408:SgK110
200410:SIK1
200411:SIK2
200412:SLK
200413:SNARK
200415:SRC
200416:SRMS
200417:SRPK1
200418:SRPK2
200419:SRPK3
200420:STK16
200421:STK33
200422:STK35
200423:STK36
200424:STK39
200425:SYK
200426:TAK1
200427:TAOK1
200428:TAOK2
200429:TAOK3
200430:TBK1
200431:TEC
200432:TESK1
200433:TGFBR1
200434:TGFBR2
200435:TIE1
200436:TIE2
200437:TLK1
200438:TLK2
200439:TNIK
200440:TNK1
200441:TNK2
200442:TNNI3K
200443:TRKA
200444:TRKB
200445:TRKC
200447:TSSK1
200448:TTK
200449:TXK
200450:TYK2(JH1domain-catalytic)
200451:TYK2(JH2domain-pseudokinase)
200454:TYRO3
200455:ULK1
200456:ULK2
200457:ULK3
200458:VGFR2
200460:WEE1
200461:WEE2
200463:YANK2
200464:YANK3
200465:YES
200466:YSK1
200467:YSK4
200468:MLTK
200469:ZAP70
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Small Molecule
Protein
% Control
Assay compound conc
Conc unit
Dactolisib
MLTK
100.0
1
uM
Dactolisib
ZAP70
100.0
1
uM
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