Binding affinity of 6 small molecule JAK inhibitors for 5 kinases - Dataset (ID:20369)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | target | relation | Kd |
|---|---|---|---|
| S-Ruxolitinib | TYK2 | = | 0.48 |
| Baricitinib | TYK2 | = | 0.29 |
| Tofacitinib | TYK2 | = | 1.9 |
| Bosutinib | TYK2 | = | 2200 |
| Nintedanib | TYK2 | = | 91 |
| Alvocidib | TYK2 | = | 320 |
| Nintedanib | JAK3 | = | 1.9 |
| S-Ruxolitinib | JAK3 | = | 2.4 |
| Baricitinib | JAK3 | = | 0.97 |
| Alvocidib | JAK3 | = | 1700 |
| Tofacitinib | JAK3 | = | 0.11 |
| Bosutinib | JAK3 | = | 210 |
| Tofacitinib | JAK2 | = | 0.58 |
| Alvocidib | JAK2 | = | 6300 |
| Nintedanib | JAK2 | = | 7.8 |
| Bosutinib | JAK2 | = | 170 |
| Baricitinib | JAK2 | = | 0.047 |
| S-Ruxolitinib | JAK2 | = | 0.18 |
| Alvocidib | JAK1 | > | 10000 |
| S-Ruxolitinib | JAK1 | = | 3.4 |
| Baricitinib | JAK1 | = | 0.38 |
| Tofacitinib | JAK1 | = | 0.55 |
| Bosutinib | JAK1 | > | 10000 |
| Nintedanib | JAK1 | = | 7800 |
| Nintedanib | DCLK3 | = | 90 |