Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | AZD8055 | 1 | 72 | 3.2 | 1745.8 | 4427.3 | 1295.5 | 0.505 | 0.183 | 0.394 | 1.773 | HCC38 AZD8055 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.001 | 4156.0 | 4578.0 | 1295.5 | -3.0 | 0.897 | 0.908 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.0032 | 3751.5 | 4578.0 | 1295.5 | -2.49 | 0.793 | 0.819 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.01 | 2607.8 | 4578.0 | 1295.5 | -2.0 | 0.468 | 0.570 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.032 | 2022.8 | 4578.0 | 1295.5 | -1.49 | 0.277 | 0.442 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.1 | 1706.5 | 4578.0 | 1295.5 | -1.0 | 0.163 | 0.373 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 0.32 | 1580.5 | 4578.0 | 1295.5 | -0.495 | 0.115 | 0.345 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 1.0 | 1416.5 | 4578.0 | 1295.5 | 0.0 | 0.050 | 0.309 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Dactolisib | 1 | 72 | 3.2 | 1202.0 | 4578.0 | 1295.5 | 0.505 | -0.040 | 0.263 | 1.821 | HCC38 BEZ235 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 0.001 | 4278.8 | 4322.0 | 1295.5 | -3.0 | 0.988 | 0.990 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 0.0032 | 4219.8 | 4322.0 | 1295.5 | -2.49 | 0.973 | 0.976 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 0.01 | 4355.0 | 4322.0 | 1295.5 | -2.0 | 1.010 | 1.010 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 0.032 | 4242.3 | 4322.0 | 1295.5 | -1.49 | 0.979 | 0.982 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 0.1 | 4265.3 | 4322.0 | 1295.5 | -1.0 | 0.985 | 0.987 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 0.32 | 3865.3 | 4322.0 | 1295.5 | -0.495 | 0.876 | 0.894 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 1.0 | 2464.8 | 4322.0 | 1295.5 | 0.0 | 0.448 | 0.570 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | Buparlisib | 1 | 72 | 3.2 | 830.8 | 4322.0 | 1295.5 | 0.505 | -0.226 | 0.192 | 1.738 | HCC38 BKM120 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 0.001 | 4350.8 | 4388.5 | 1295.5 | -3.0 | 0.990 | 0.991 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 0.0032 | 4427.0 | 4388.5 | 1295.5 | -2.49 | 1.010 | 1.010 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 0.01 | 4389.8 | 4388.5 | 1295.5 | -2.0 | 1.000 | 1.000 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 0.032 | 4512.3 | 4388.5 | 1295.5 | -1.49 | 1.030 | 1.030 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 0.1 | 4372.0 | 4388.5 | 1295.5 | -1.0 | 0.996 | 0.996 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 0.32 | 4088.5 | 4388.5 | 1295.5 | -0.495 | 0.921 | 0.932 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 1.0 | 858.8 | 4388.5 | 1295.5 | 0.0 | -0.208 | 0.196 | 1.760 | HCC38 BX912 0 1 72 |
| HCC38 | BX-912 | 1 | 72 | 3.2 | 654.3 | 4388.5 | 1295.5 | 0.505 | -0.322 | 0.149 | 1.760 | HCC38 BX912 0 1 72 |