Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | WYE-125132 | 1 | 72 | 1.0 | 1872.5 | 5366.3 | 1554.9 | 0.0 | 0.110 | 0.349 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | WYE-125132 | 1 | 72 | 3.2 | 1936.5 | 5366.3 | 1554.9 | 0.505 | 0.131 | 0.361 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.001 | 4921.8 | 5624.3 | 1554.9 | -3.0 | 0.861 | 0.875 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.0032 | 5444.0 | 5624.3 | 1554.9 | -2.49 | 0.965 | 0.968 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.01 | 5568.8 | 5624.3 | 1554.9 | -2.0 | 0.989 | 0.990 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.032 | 5383.3 | 5624.3 | 1554.9 | -1.49 | 0.953 | 0.957 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.1 | 5584.3 | 5624.3 | 1554.9 | -1.0 | 0.992 | 0.993 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.32 | 5476.0 | 5624.3 | 1554.9 | -0.495 | 0.971 | 0.974 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 1.0 | 5410.8 | 5624.3 | 1554.9 | 0.0 | 0.959 | 0.962 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 3.2 | 5318.0 | 5624.3 | 1554.9 | 0.505 | 0.941 | 0.946 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.001 | 5313.0 | 5649.0 | 1554.9 | -3.0 | 0.935 | 0.941 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.0032 | 5402.5 | 5649.0 | 1554.9 | -2.49 | 0.953 | 0.956 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.01 | 5438.8 | 5649.0 | 1554.9 | -2.0 | 0.960 | 0.963 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.032 | 5268.8 | 5649.0 | 1554.9 | -1.49 | 0.926 | 0.933 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.1 | 4613.8 | 5649.0 | 1554.9 | -1.0 | 0.794 | 0.817 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.32 | 3782.8 | 5649.0 | 1554.9 | -0.495 | 0.612 | 0.670 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 1.0 | 2875.0 | 5649.0 | 1554.9 | 0.0 | 0.391 | 0.509 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 3.2 | 2228.3 | 5649.0 | 1554.9 | 0.505 | 0.213 | 0.394 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | AS605240 | 2 | 72 | 0.001 | 4612.0 | 4866.0 | 1249.6 | -3.0 | 0.946 | 0.948 | 1.961 | BT549 AS605240 0 2 72 |
| BT-549 | AS605240 | 2 | 72 | 0.0032 | 4819.5 | 4866.0 | 1249.6 | -2.49 | 0.990 | 0.990 | 1.961 | BT549 AS605240 0 2 72 |
| BT-549 | AS605240 | 2 | 72 | 0.01 | 4608.0 | 4866.0 | 1249.6 | -2.0 | 0.945 | 0.947 | 1.961 | BT549 AS605240 0 2 72 |
| BT-549 | AS605240 | 2 | 72 | 0.032 | 4901.5 | 4866.0 | 1249.6 | -1.49 | 1.010 | 1.010 | 1.961 | BT549 AS605240 0 2 72 |
| BT-549 | AS605240 | 2 | 72 | 0.1 | 4548.5 | 4866.0 | 1249.6 | -1.0 | 0.932 | 0.935 | 1.961 | BT549 AS605240 0 2 72 |
| BT-549 | AS605240 | 2 | 72 | 0.32 | 4612.0 | 4866.0 | 1249.6 | -0.495 | 0.946 | 0.948 | 1.961 | BT549 AS605240 0 2 72 |
| BT-549 | AS605240 | 2 | 72 | 1.0 | 4471.0 | 4866.0 | 1249.6 | 0.0 | 0.916 | 0.919 | 1.961 | BT549 AS605240 0 2 72 |