Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-20 Alpelisib 1 72
0.01
6056.3 6091.5 1443.3
-2.0
0.994 0.994 2.077
BT20 BYL719 0 1
BT-20 Alpelisib 1 72
0.032
5912.0 6091.5 1443.3
-1.49
0.971 0.971 2.077
BT20 BYL719 0 1
BT-20 Alpelisib 1 72
0.1
5660.0 6091.5 1443.3
-1.0
0.931 0.929 2.077
BT20 BYL719 0 1
BT-20 Alpelisib 1 72
0.32
5140.8 6091.5 1443.3
-0.495
0.843 0.844 2.077
BT20 BYL719 0 1
BT-20 Alpelisib 1 72
1.0
3559.0 6091.5 1443.3
0.0
0.544 0.584 2.077
BT20 BYL719 0 1
BT-20 Alpelisib 1 72
3.2
1584.5 6091.5 1443.3
0.505
0.046 0.260 2.077
BT20 BYL719 0 1
BT-20 CAL-101 1 72
0.001
5598.0 6240.0 1443.3
-3.0
0.900 0.897 2.112
BT20 CAL101 0 1
BT-20 CAL-101 1 72
0.0032
5972.5 6240.0 1443.3
-2.49
0.959 0.957 2.112
BT20 CAL101 0 1
BT-20 CAL-101 1 72
0.01
5904.0 6240.0 1443.3
-2.0
0.948 0.946 2.112
BT20 CAL101 0 1
BT-20 CAL-101 1 72
0.032
6025.0 6240.0 1443.3
-1.49
0.967 0.966 2.112
BT20 CAL101 0 1
BT-20 CAL-101 1 72
0.1
6019.8 6240.0 1443.3
-1.0
0.966 0.965 2.112
BT20 CAL101 0 1
BT-20 CAL-101 1 72
0.32
6047.5 6240.0 1443.3
-0.495
0.971 0.969 2.112
BT20 CAL101 0 1
BT-20 CAL-101 1 72
1.0
5741.0 6240.0 1443.3
0.0
0.923 0.920 2.112
BT20 CAL101 0 1
BT-20 CAL-101 1 72
3.2
5408.0 6240.0 1443.3
0.505
0.869 0.867 2.112
BT20 CAL101 0 1
BT-20 Everolimus 1 72
0.001
3773.0 5781.0 1443.3
-3.0
0.616 0.653 2.002
BT20 Everolimus 0 1
BT-20 Everolimus 1 72
0.0032
3719.8 5781.0 1443.3
-2.49
0.605 0.643 2.002
BT20 Everolimus 0 1
BT-20 Everolimus 1 72
0.01
3784.5 5781.0 1443.3
-2.0
0.619 0.655 2.002
BT20 Everolimus 0 1
BT-20 Everolimus 1 72
0.032
3677.3 5781.0 1443.3
-1.49
0.595 0.636 2.002
BT20 Everolimus 0 1
BT-20 Everolimus 1 72
0.1
3707.8 5781.0 1443.3
-1.0
0.602 0.641 2.002
BT20 Everolimus 0 1
BT-20 Everolimus 1 72
0.32
3776.0 5781.0 1443.3
-0.495
0.617 0.653 2.002
BT20 Everolimus 0 1
BT-20 Everolimus 1 72
1.0
3532.8 5781.0 1443.3
0.0
0.564 0.611 2.002
BT20 Everolimus 0 1
BT-20 Everolimus 1 72
3.2
3453.3 5781.0 1443.3
0.505
0.546 0.597 2.002
BT20 Everolimus 0 1
BT-20 Pictilisib 1 72
0.001
5849.5 6125.0 1443.3
-3.0
0.956 0.955 2.085
BT20 GDC0941 0 1
BT-20 Pictilisib 1 72
0.0032
6083.5 6125.0 1443.3
-2.49
0.993 0.993 2.085
BT20 GDC0941 0 1
BT-20 Pictilisib 1 72
0.01
6061.5 6125.0 1443.3
-2.0
0.990 0.990 2.085
BT20 GDC0941 0 1