Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Dactolisib | 1 | 72 | 0.0032 | 4990.8 | 5998.3 | 1443.3 | -2.49 | 0.829 | 0.832 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 0.01 | 3537.3 | 5998.3 | 1443.3 | -2.0 | 0.547 | 0.590 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 0.032 | 2781.3 | 5998.3 | 1443.3 | -1.49 | 0.376 | 0.464 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 0.1 | 2350.5 | 5998.3 | 1443.3 | -1.0 | 0.268 | 0.392 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 0.32 | 1891.3 | 5998.3 | 1443.3 | -0.495 | 0.141 | 0.315 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 1.0 | 1253.8 | 5998.3 | 1443.3 | 0.0 | -0.066 | 0.209 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 3.2 | 900.5 | 5998.3 | 1443.3 | 0.505 | -0.205 | 0.150 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 0.001 | 5907.8 | 6321.8 | 1443.3 | -3.0 | 0.937 | 0.935 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 0.0032 | 5963.5 | 6321.8 | 1443.3 | -2.49 | 0.946 | 0.943 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 0.01 | 6064.3 | 6321.8 | 1443.3 | -2.0 | 0.961 | 0.959 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 0.032 | 5943.0 | 6321.8 | 1443.3 | -1.49 | 0.943 | 0.940 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 0.1 | 5653.8 | 6321.8 | 1443.3 | -1.0 | 0.898 | 0.894 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 0.32 | 4940.0 | 6321.8 | 1443.3 | -0.495 | 0.781 | 0.781 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 1.0 | 2154.3 | 6321.8 | 1443.3 | 0.0 | 0.207 | 0.341 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 3.2 | 495.8 | 6321.8 | 1443.3 | 0.505 | -0.394 | 0.078 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | BX-912 | 1 | 72 | 0.001 | 5809.5 | 6155.0 | 1443.3 | -3.0 | 0.946 | 0.944 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 1 | 72 | 0.0032 | 6025.8 | 6155.0 | 1443.3 | -2.49 | 0.980 | 0.979 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 1 | 72 | 0.01 | 5991.8 | 6155.0 | 1443.3 | -2.0 | 0.974 | 0.973 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 1 | 72 | 0.032 | 6288.0 | 6155.0 | 1443.3 | -1.49 | 1.020 | 1.020 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 1 | 72 | 0.1 | 6133.0 | 6155.0 | 1443.3 | -1.0 | 0.997 | 0.996 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 1 | 72 | 0.32 | 5888.8 | 6155.0 | 1443.3 | -0.495 | 0.958 | 0.957 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 1 | 72 | 1.0 | 5764.8 | 6155.0 | 1443.3 | 0.0 | 0.938 | 0.937 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 1 | 72 | 3.2 | 4618.5 | 6155.0 | 1443.3 | 0.505 | 0.743 | 0.750 | 2.092 | BT20 BX912 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.001 | 5809.8 | 6091.5 | 1443.3 | -3.0 | 0.955 | 0.954 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.0032 | 5159.8 | 6091.5 | 1443.3 | -2.49 | 0.846 | 0.847 | 2.077 | BT20 BYL719 0 1 |