Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | GDC-0980 | 2 | 72 | 0.032 | 2409.5 | 3217.8 | 1018.6 | -1.49 | 0.680 | 0.749 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 0.1 | 1119.8 | 3217.8 | 1018.6 | -1.0 | 0.059 | 0.348 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 0.32 | 749.3 | 3217.8 | 1018.6 | -0.495 | -0.169 | 0.233 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 1.0 | 611.3 | 3217.8 | 1018.6 | 0.0 | -0.265 | 0.190 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | GDC-0980 | 2 | 72 | 3.2 | 420.0 | 3217.8 | 1018.6 | 0.505 | -0.414 | 0.131 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.001 | 3128.0 | 3349.0 | 1018.6 | -3.0 | 0.922 | 0.934 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.0032 | 2069.3 | 3349.0 | 1018.6 | -2.49 | 0.511 | 0.618 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.01 | 1065.3 | 3349.0 | 1018.6 | -2.0 | 0.026 | 0.318 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.032 | 647.3 | 3349.0 | 1018.6 | -1.49 | -0.232 | 0.193 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.1 | 664.8 | 3349.0 | 1018.6 | -1.0 | -0.220 | 0.199 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.32 | 541.3 | 3349.0 | 1018.6 | -0.495 | -0.308 | 0.162 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 1.0 | 235.0 | 3349.0 | 1018.6 | 0.0 | -0.574 | 0.070 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 3.2 | 65.0 | 3349.0 | 1018.6 | 0.505 | -0.799 | 0.019 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.001 | 3248.0 | 3407.5 | 1018.6 | -3.0 | 0.946 | 0.953 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.0032 | 3318.0 | 3407.5 | 1018.6 | -2.49 | 0.970 | 0.974 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.01 | 3231.8 | 3407.5 | 1018.6 | -2.0 | 0.940 | 0.948 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.032 | 3303.0 | 3407.5 | 1018.6 | -1.49 | 0.965 | 0.969 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.1 | 3321.3 | 3407.5 | 1018.6 | -1.0 | 0.971 | 0.975 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.32 | 3166.5 | 3407.5 | 1018.6 | -0.495 | 0.918 | 0.929 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 1.0 | 3085.0 | 3407.5 | 1018.6 | 0.0 | 0.889 | 0.905 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 3.2 | 2975.3 | 3407.5 | 1018.6 | 0.505 | 0.850 | 0.873 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | MK2206 | 2 | 72 | 0.001 | 3054.5 | 3399.5 | 1018.6 | -3.0 | 0.881 | 0.899 | 1.739 | BT20 MK2206 0 2 |
| BT-20 | MK2206 | 2 | 72 | 0.0032 | 3084.5 | 3399.5 | 1018.6 | -2.49 | 0.891 | 0.907 | 1.739 | BT20 MK2206 0 2 |
| BT-20 | MK2206 | 2 | 72 | 0.01 | 3214.5 | 3399.5 | 1018.6 | -2.0 | 0.937 | 0.946 | 1.739 | BT20 MK2206 0 2 |
| BT-20 | MK2206 | 2 | 72 | 0.032 | 3225.5 | 3399.5 | 1018.6 | -1.49 | 0.940 | 0.949 | 1.739 | BT20 MK2206 0 2 |