Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | CAL-101 | 3 | 72 | 1.0 | 11624.3 | 11282.8 | 1273.3 | 0.0 | 1.020 | 1.030 | 3.147 | HCC1806 CAL101 0 3 72 |
| HCC1806 | CAL-101 | 3 | 72 | 3.2 | 11994.0 | 11282.8 | 1273.3 | 0.505 | 1.040 | 1.060 | 3.147 | HCC1806 CAL101 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 0.001 | 10053.0 | 12020.5 | 1273.3 | -3.0 | 0.893 | 0.836 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 0.0032 | 9348.8 | 12020.5 | 1273.3 | -2.49 | 0.851 | 0.778 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 0.01 | 9417.5 | 12020.5 | 1273.3 | -2.0 | 0.855 | 0.783 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 0.032 | 9329.3 | 12020.5 | 1273.3 | -1.49 | 0.849 | 0.776 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 0.1 | 9054.3 | 12020.5 | 1273.3 | -1.0 | 0.832 | 0.753 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 0.32 | 9042.0 | 12020.5 | 1273.3 | -0.495 | 0.832 | 0.752 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 1.0 | 8742.8 | 12020.5 | 1273.3 | 0.0 | 0.813 | 0.727 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Everolimus | 3 | 72 | 3.2 | 8863.5 | 12020.5 | 1273.3 | 0.505 | 0.820 | 0.737 | 3.239 | HCC1806 Everolimus 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.001 | 11432.3 | 11984.0 | 1273.3 | -3.0 | 0.971 | 0.954 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.0032 | 11408.5 | 11984.0 | 1273.3 | -2.49 | 0.970 | 0.952 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.01 | 11154.5 | 11984.0 | 1273.3 | -2.0 | 0.956 | 0.931 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.032 | 11917.8 | 11984.0 | 1273.3 | -1.49 | 0.997 | 0.994 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.1 | 11495.5 | 11984.0 | 1273.3 | -1.0 | 0.974 | 0.959 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 0.32 | 11380.8 | 11984.0 | 1273.3 | -0.495 | 0.968 | 0.950 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 1.0 | 10951.3 | 11984.0 | 1273.3 | 0.0 | 0.945 | 0.914 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | Pictilisib | 3 | 72 | 3.2 | 8798.5 | 11984.0 | 1273.3 | 0.505 | 0.818 | 0.734 | 3.234 | HCC1806 GDC0941 0 3 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.001 | 11516.0 | 11293.0 | 1273.3 | -3.0 | 1.010 | 1.020 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.0032 | 11217.3 | 11293.0 | 1273.3 | -2.49 | 0.996 | 0.993 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.01 | 11207.3 | 11293.0 | 1273.3 | -2.0 | 0.995 | 0.992 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.032 | 11461.8 | 11293.0 | 1273.3 | -1.49 | 1.010 | 1.010 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.1 | 10419.3 | 11293.0 | 1273.3 | -1.0 | 0.949 | 0.923 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 0.32 | 7985.5 | 11293.0 | 1273.3 | -0.495 | 0.792 | 0.707 | 3.149 | HCC1806 GDC0980 0 3 72 |
| HCC1806 | GDC-0980 | 3 | 72 | 1.0 | 5800.0 | 11293.0 | 1273.3 | 0.0 | 0.619 | 0.514 | 3.149 | HCC1806 GDC0980 0 3 72 |