Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-20 CAL-101 2 72
0.01
 3257.5 3469.3 1018.6
-2.0
 0.930 0.939 1.768
BT20 CAL101 0 2
BT-20 CAL-101 2 72
0.032
 3284.0 3469.3 1018.6
-1.49
 0.939 0.947 1.768
BT20 CAL101 0 2
BT-20 CAL-101 2 72
0.1
 3213.0 3469.3 1018.6
-1.0
 0.915 0.926 1.768
BT20 CAL101 0 2
BT-20 CAL-101 2 72
0.32
 3269.3 3469.3 1018.6
-0.495
 0.934 0.942 1.768
BT20 CAL101 0 2
BT-20 CAL-101 2 72
1.0
 3064.8 3469.3 1018.6
0.0
 0.865 0.883 1.768
BT20 CAL101 0 2
BT-20 CAL-101 2 72
3.2
 2930.8 3469.3 1018.6
0.505
 0.818 0.845 1.768
BT20 CAL101 0 2
BT-20 Everolimus 2 72
0.001
 1803.0 3213.5 1018.6
-3.0
 0.411 0.561 1.658
BT20 Everolimus 0 2
BT-20 Everolimus 2 72
0.0032
 1773.8 3213.5 1018.6
-2.49
 0.397 0.552 1.658
BT20 Everolimus 0 2
BT-20 Everolimus 2 72
0.01
 1863.0 3213.5 1018.6
-2.0
 0.439 0.580 1.658
BT20 Everolimus 0 2
BT-20 Everolimus 2 72
0.032
 1675.5 3213.5 1018.6
-1.49
 0.350 0.521 1.658
BT20 Everolimus 0 2
BT-20 Everolimus 2 72
0.1
 1800.3 3213.5 1018.6
-1.0
 0.410 0.560 1.658
BT20 Everolimus 0 2
BT-20 Everolimus 2 72
0.32
 1752.8 3213.5 1018.6
-0.495
 0.387 0.545 1.658
BT20 Everolimus 0 2
BT-20 Everolimus 2 72
1.0
 1591.0 3213.5 1018.6
0.0
 0.309 0.495 1.658
BT20 Everolimus 0 2
BT-20 Everolimus 2 72
3.2
 1212.8 3213.5 1018.6
0.505
 0.111 0.377 1.658
BT20 Everolimus 0 2
BT-20 Pictilisib 2 72
0.001
 2270.3 3416.0 1018.6
-3.0
 0.583 0.665 1.746
BT20 GDC0941 0 2
BT-20 Pictilisib 2 72
0.0032
 2966.0 3416.0 1018.6
-2.49
 0.845 0.868 1.746
BT20 GDC0941 0 2
BT-20 Pictilisib 2 72
0.01
 3176.8 3416.0 1018.6
-2.0
 0.919 0.930 1.746
BT20 GDC0941 0 2
BT-20 Pictilisib 2 72
0.032
 2994.5 3416.0 1018.6
-1.49
 0.855 0.877 1.746
BT20 GDC0941 0 2
BT-20 Pictilisib 2 72
0.1
 2930.8 3416.0 1018.6
-1.0
 0.832 0.858 1.746
BT20 GDC0941 0 2
BT-20 Pictilisib 2 72
0.32
 2142.8 3416.0 1018.6
-0.495
 0.531 0.627 1.746
BT20 GDC0941 0 2
BT-20 Pictilisib 2 72
1.0
 1217.8 3416.0 1018.6
0.0
 0.108 0.356 1.746
BT20 GDC0941 0 2
BT-20 Pictilisib 2 72
3.2
 927.8 3416.0 1018.6
0.505
 -0.052 0.272 1.746
BT20 GDC0941 0 2
BT-20 GDC-0980 2 72
0.001
 3333.5 3217.8 1018.6
-3.0
 1.040 1.040 1.659
BT20 GDC0980 0 2
BT-20 GDC-0980 2 72
0.0032
 3107.8 3217.8 1018.6
-2.49
 0.959 0.966 1.659
BT20 GDC0980 0 2
BT-20 GDC-0980 2 72
0.01
 3079.3 3217.8 1018.6
-2.0
 0.948 0.957 1.659
BT20 GDC0980 0 2