Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC1806 AS605240 2 72
0.1
 11678.3 11546.3 1643.3
-1.0
 1.010 1.010 2.813
HCC1806 AS605240 0 2 72
HCC1806 AS605240 2 72
0.32
 11293.3 11546.3 1643.3
-0.495
 0.984 0.978 2.813
HCC1806 AS605240 0 2 72
HCC1806 AS605240 2 72
1.0
 10421.8 11546.3 1643.3
0.0
 0.928 0.903 2.813
HCC1806 AS605240 0 2 72
HCC1806 AS605240 2 72
3.2
 10191.5 11546.3 1643.3
0.505
 0.913 0.883 2.813
HCC1806 AS605240 0 2 72
HCC1806 AZD-6482 2 72
0.001
 11446.8 11709.8 1643.3
-3.0
 0.984 0.978 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD-6482 2 72
0.0032
 11393.8 11709.8 1643.3
-2.49
 0.981 0.973 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD-6482 2 72
0.01
 11388.3 11709.8 1643.3
-2.0
 0.980 0.973 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD-6482 2 72
0.032
 11940.3 11709.8 1643.3
-1.49
 1.010 1.020 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD-6482 2 72
0.1
 12053.8 11709.8 1643.3
-1.0
 1.020 1.030 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD-6482 2 72
0.32
 11558.3 11709.8 1643.3
-0.495
 0.991 0.987 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD-6482 2 72
1.0
 11781.3 11709.8 1643.3
0.0
 1.000 1.010 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD-6482 2 72
3.2
 11967.3 11709.8 1643.3
0.505
 1.020 1.020 2.833
HCC1806 AZD6482 0 2 72
HCC1806 AZD8055 2 72
0.001
 11605.5 11579.3 1643.3
-3.0
 1.000 1.000 2.817
HCC1806 AZD8055 0 2 72
HCC1806 AZD8055 2 72
0.0032
 11161.5 11579.3 1643.3
-2.49
 0.974 0.964 2.817
HCC1806 AZD8055 0 2 72
HCC1806 AZD8055 2 72
0.01
 10460.5 11579.3 1643.3
-2.0
 0.929 0.903 2.817
HCC1806 AZD8055 0 2 72
HCC1806 AZD8055 2 72
0.032
 9150.5 11579.3 1643.3
-1.49
 0.840 0.790 2.817
HCC1806 AZD8055 0 2 72
HCC1806 AZD8055 2 72
0.1
 7212.5 11579.3 1643.3
-1.0
 0.691 0.623 2.817
HCC1806 AZD8055 0 2 72
HCC1806 AZD8055 2 72
0.32
 5696.0 11579.3 1643.3
-0.495
 0.555 0.492 2.817
HCC1806 AZD8055 0 2 72
HCC1806 AZD8055 2 72
1.0
 5727.5 11579.3 1643.3
0.0
 0.558 0.495 2.817
HCC1806 AZD8055 0 2 72
HCC1806 AZD8055 2 72
3.2
 5607.0 11579.3 1643.3
0.505
 0.546 0.484 2.817
HCC1806 AZD8055 0 2 72
HCC1806 Dactolisib 2 72
0.001
 11630.8 11670.0 1643.3
-3.0
 0.998 0.997 2.828
HCC1806 BEZ235 0 2 72
HCC1806 Dactolisib 2 72
0.0032
 10570.3 11670.0 1643.3
-2.49
 0.931 0.906 2.828
HCC1806 BEZ235 0 2 72
HCC1806 Dactolisib 2 72
0.01
 9243.3 11670.0 1643.3
-2.0
 0.842 0.792 2.828
HCC1806 BEZ235 0 2 72
HCC1806 Dactolisib 2 72
0.032
 7096.0 11670.0 1643.3
-1.49
 0.677 0.608 2.828
HCC1806 BEZ235 0 2 72
HCC1806 Dactolisib 2 72
0.1
 6060.8 11670.0 1643.3
-1.0
 0.586 0.519 2.828
HCC1806 BEZ235 0 2 72