Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.6924 | 0.1460 | 0.0085 | 1.6543 | 0.024125 | 0.93749 |
| CAL-120 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9240 | 0.0139 | -0.0025 | 0.0000 | Inf | 0.39826 |
| PDX1328 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.2825 | 0.6902 | 0.0347 | 0.0000 | Inf | 0.15246 |
| HCC1937 | A-1210477 | Mcl-1 | Misc | Inf | 0.7240 | 0.0060 | 0.0046 | 4.0529 | 5.9209 | 0.95858 |
| MCF 10A | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.7207 | 0.0475 | -0.0020 | 1.0315 | 4.381 | 0.99443 |
| MCF 10A | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7889 | 0.1130 | 0.0000 | 0.4668 | 0.070049 | 0.96385 |
| MCF 10A | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9505 | 0.0050 | 0.0003 | 0.8181 | 270.4333 | 0.86411 |
| CAL-85-1 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.4714 | 0.1662 | -0.0047 | 1.3900 | 0.27338 | 0.96561 |
| MCF 10A | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.6472 | 0.0600 | -0.0019 | 1.0758 | 4.7959 | 0.99868 |
| CAL-85-1 | A-1210477 | Mcl-1 | Misc | Inf | 1.0052 | 0.0109 | 0.0047 | 0.0000 | Inf | 0.20764 |
| MCF 10A | A-1210477 | Mcl-1 | Misc | Inf | 0.9527 | 0.0018 | 0.0006 | 4.5125 | 3.8181 | 0.94609 |
| HCC1937 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.5349 | 0.1565 | 0.0058 | 1.0014 | 0.36202 | 0.97156 |
| MCF 10A | ABT-737 | Bcl2/XL | Misc | Inf | 0.8170 | 0.0104 | 0.0055 | 4.1268 | 4.3547 | 0.98669 |
| HCC1937 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8377 | 0.0202 | 0.0070 | 0.6226 | 52.0493 | 0.74303 |
| CAL-85-1 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9343 | -0.0283 | 0.0138 | 0.0000 | Inf | -0.025903 |
| HCC1937 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.6324 | 0.3348 | 0.0206 | 0.4211 | 0.00012787 | 0.92563 |
| HCC1937 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.7688 | 0.0390 | 0.0001 | 0.6190 | 21.7234 | 0.88762 |
| Hs 578T | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9143 | 0.0252 | 0.0005 | 2.0096 | 0.1778 | 0.76824 |
| SUM159PT | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.5642 | 0.1850 | 0.0047 | 1.3689 | 0.14044 | 0.98104 |
| HCC1954 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.5256 | 0.1839 | -0.0048 | 1.2148 | 0.056374 | 0.97285 |
| HCC1954 | A-1210477 | Mcl-1 | Misc | Inf | 0.8844 | -0.0259 | 0.0076 | 0.0000 | Inf | 0.43063 |
| Hs 578T | A-1210477 | Mcl-1 | Misc | Inf | 0.9419 | -0.0065 | -0.0001 | 0.0000 | Inf | 0.41975 |
| Hs 578T | ABT-737 | Bcl2/XL | Misc | Inf | 0.7755 | 0.0260 | 0.0177 | 1.3421 | 4.2689 | 0.94189 |
| HCC1954 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9607 | -0.0374 | -0.0050 | 0.0000 | Inf | -1.0282 |
| HCC1954 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.3263 | 0.6531 | 0.1358 | 0.0000 | Inf | 0.52018 |