Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
---|---|---|---|---|---|---|---|---|---|---|
HCC1937 | Olaparib | PARP | Misc | 26.5474 | 0.6855 | 0.0584 | 0.0092 | 0.6339 | 150.1948 | 0.9681 |
SUM149PT | INK-128 | mTORC1/2 | PI3K/mTOR | 0.16131 | 0.2613 | 0.3199 | 0.0092 | 0.6928 | 0.056936 | 0.98747 |
HCC38 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.7055 | 0.1225 | 0.0092 | 1.1410 | 0.22841 | 0.9721 |
HCC38 | Alpelisib | PI3Ka | PI3K/mTOR | 22.4126 | 0.6801 | 0.0440 | 0.0092 | 0.7155 | 102.9667 | 0.92013 |
Hs 578T | Ipatasertib | AKT | PI3K/mTOR | 4.5924 | 0.4423 | 0.2458 | 0.0093 | 0.5006 | 0.34659 | 0.98155 |
MDA-MB-361 | ABT-737 | Bcl2/XL | Misc | Inf | 0.8441 | -0.0067 | 0.0094 | 2.5452 | 4.5021 | 0.68512 |
MDA-MB-468 | PF-4708671 | p70S6K | PI3K/mTOR | 4.1732 | 0.0813 | 0.1176 | 0.0094 | 1.1782 | 8.8804 | 0.99743 |
MDA-MB-361 | Olaparib | PARP | Misc | 4.8624 | 0.0945 | 0.1038 | 0.0095 | 1.2844 | 11.0203 | 0.97233 |
HCC1954 | Olaparib | PARP | Misc | 11.1008 | 0.5266 | 0.0536 | 0.0095 | 1.2000 | 8.359 | 0.96291 |
MDA-MB-231 | Etoposide | Topo II | Chemotherapy | 0.7036 | 0.1203 | 0.2978 | 0.0095 | 1.5558 | 0.62323 | 0.99162 |
BT-549 | Cabozantinib | VEGFR2/MET | RTK | 10.1855 | 0.5329 | 0.0124 | 0.0096 | 5.0000 | 12.5665 | 0.95054 |
MDA-MB-134-VI | Ipatasertib | AKT | PI3K/mTOR | 8.0392 | 0.4925 | 0.0150 | 0.0096 | 4.9968 | 3.7717 | 0.94642 |
HCC1428 | Cisplatin | Chemo | Chemotherapy | 0.91164 | 0.1223 | 0.2655 | 0.0096 | 1.2004 | 0.80529 | 0.9803 |
MDA-MB-157 | Olaparib | PARP | Misc | 5.3864 | 0.1575 | 0.1149 | 0.0097 | 1.2271 | 13.1864 | 0.97814 |
BT-549 | Ipatasertib | AKT | PI3K/mTOR | 12.6362 | 0.4956 | 0.1735 | 0.0097 | 0.5079 | 1.6786 | 0.97652 |
MDA-MB-436 | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.6528 | 0.1022 | 0.0098 | 0.0000 | Inf | 0.40773 |
SUM149PT | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7389 | 0.2003 | 0.0098 | 0.2094 | 0.00021362 | 0.67353 |
SUM1315MO2 | Ipatasertib | AKT | PI3K/mTOR | 36.6304 | 0.6070 | 0.1242 | 0.0099 | 0.3263 | 999.2697 | 0.9146 |
BT-549 | Alpelisib | PI3Ka | PI3K/mTOR | 17.5141 | 0.6841 | 0.0322 | 0.0099 | 1.0429 | 49.8384 | 0.95639 |
MDA-MB-231 | Palbociclib | CDK4/6 | Cell cycle | 0.11065 | 0.2066 | 0.3469 | 0.0101 | 0.7428 | 0.05699 | 0.98815 |
Hs 578T | Olaparib | PARP | Misc | 8.9082 | 0.4435 | 0.0997 | 0.0101 | 1.0369 | 25.6993 | 0.93656 |
BT-20 | PF-4708671 | p70S6K | PI3K/mTOR | 15.1446 | 0.6601 | 0.0129 | 0.0102 | 1.1942 | 37.9666 | 0.89476 |
SK-BR-3 | Saracatinib | SRC | MAPK/nRTK | 4.9166 | 0.2786 | 0.0221 | 0.0102 | 5.0000 | 4.2128 | 0.96696 |
Hs 578T | TGX221 | PI3Kb | PI3K/mTOR | 34.4921 | 0.7094 | 0.0668 | 0.0103 | 0.5623 | 243.351 | 0.9333 |
MDA-MB-134-VI | Bleomycin | Radiation | Misc | 1.7911 | 0.0193 | 0.2734 | 0.0108 | 0.5040 | 15.841 | 0.87961 |