Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1419 Olaparib
PARP
Misc
Inf
 0.6322 0.0273 -0.0012 2.1535
5.2752
0.95353
HCC1395 Vorinostat
HDAC
Misc
3.2812
 -0.0589 0.1137 0.0365 2.1496
3.8175
0.99171
HCC1428 Volasertib
PLK
Cell cycle
0.018634
 -0.0388 0.4063 0.0917 2.1456
0.018507
0.99276
MCF 10A Cisplatin
Chemo
Chemotherapy
4.2937
 0.3794 0.0952 0.0149 2.1287
2.4561
0.99519
MDA-MB-468 Buparlisib
pan PI3K
PI3K/mTOR
0.83168
 -0.5157 0.3573 0.2010 2.1267
1.1738
0.99824
HCC1937 Tivantinib
MET
RTK
0.64919
 -0.0621 0.2925 0.0799 2.1267
0.69626
0.99463
CAL-85-1 Abemaciclib
CDK4/6
Cell cycle
1.3003
 -0.2236 0.2357 0.0485 2.1239
1.5776
0.99317
CAL-85-1 Dinaciclib
pan CDK
Cell cycle
0.0046904
 -0.2406 0.6880 0.1122 2.1120
0.005589
0.99744
HCC1419 Vorinostat
HDAC
Misc
1.735
 -0.2557 0.1917 0.0407 2.1116
2.1704
0.99173
MDA-MB-468 Topotecan
Topo I
Chemotherapy
0.015779
 -0.6577 1.0692 0.4464 2.1036
0.023029
0.99528
HCC70 Etoposide
Topo II
Chemotherapy
0.36498
 -0.1518 0.4535 0.0513 2.1004
0.41879
0.96872
SUM1315MO2 Doxorubicin
Chemo
Chemotherapy
0.018222
 -0.0635 0.5132 0.1324 2.0980
0.016338
0.96491
SUM159PT Tivantinib
MET
RTK
0.37997
 -0.1921 0.3954 0.1806 2.0717
0.4458
0.9982
BT-20 Taxol
Chemo
Chemotherapy
0.0020158
 -0.5760 0.9854 0.4456 2.0677
0.0028795
0.99355
Hs 578T Tivantinib
MET
RTK
0.33668
 -0.3204 0.4411 0.2071 2.0560
0.42597
0.99878
HCC1419 AZD7762
CHK1/2
Cell cycle
0.068618
 -0.0826 0.5614 0.1156 2.0553
0.072481
0.98917
MDA-MB-361 AZD7762
CHK1/2
Cell cycle
0.0076402
 -0.6753 1.0533 0.2116 2.0458
0.010426
0.97675
CAL-85-1 Volasertib
PLK
Cell cycle
0.0032652
 -0.2891 0.7316 0.1652 2.0442
0.0039314
0.99429
HCC1419 Luminespib
HSP90
Misc
0.0069643
 -0.2968 0.6506 0.1579 2.0439
0.0087353
0.99699
HCC38 AZD7762
CHK1/2
Cell cycle
0.0094764
 -0.3341 0.9185 0.2951 2.0434
0.01177
0.98869
HCC70 Doxorubicin
Chemo
Chemotherapy
0.010621
 -0.7794 0.7867 0.1459 2.0410
0.014138
0.93856
Hs 578T Etoposide
Topo II
Chemotherapy
0.41322
 -0.1361 0.3770 0.1666 2.0332
0.46109
0.99901
CAMA-1 Dinaciclib
pan CDK
Cell cycle
0.014558
 -0.4849 0.6062 0.1927 2.0283
0.019954
0.99839
CAL-85-1 Taxol
Chemo
Chemotherapy
0.0027273
 -0.3464 0.7931 0.3351 2.0210
0.0033785
0.95638
BT-549 Buparlisib
pan PI3K
PI3K/mTOR
1.419
 -0.2716 0.2487 0.0802 2.0178
1.8107
0.99484