Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| T47D | Cisplatin | Chemo | Chemotherapy | 1.5698 | 0.1019 | 0.2147 | 0.0055 | 1.3290 | 1.5705 | 0.98121 |
| T47D | Ceritinib | ALK | RTK | 1.5629 | -0.8550 | 0.3123 | 0.1208 | 1.6029 | 3.1015 | 0.97809 |
| T47D | Abemaciclib | CDK4/6 | Cell cycle | 0.0042816 | -0.0412 | 0.7664 | 0.0265 | 1.3858 | 0.0037683 | 0.95899 |
| T47D | Palbociclib | CDK4/6 | Cell cycle | 0.027507 | 0.1166 | 0.4501 | 0.0077 | 1.5536 | 0.022367 | 0.99262 |
| T47D | Everolimus | mTOR1 | PI3K/mTOR | -Inf | 0.2975 | 0.6157 | 0.0150 | 0.1000 | 5.9599e-07 | 0.77906 |
| T47D | Dasatinib | BCR/ABL | MAPK/nRTK | 12.5697 | 0.4961 | 0.1933 | 0.0086 | 0.2753 | 679.7315 | 0.95229 |
| T47D | Vorinostat | HDAC | Misc | 1.8007 | -0.1567 | 0.1750 | 0.0409 | 2.2684 | 2.0704 | 0.99157 |
| T47D | A-1210477 | Mcl-1 | Misc | Inf | 0.5752 | 0.0227 | 0.0055 | 5.0000 | 3.7781 | 0.96287 |
| T47D | Olaparib | PARP | Misc | Inf | 0.5304 | 0.0302 | 0.0015 | 4.9632 | 3.5388 | 0.95841 |
| SUM159PT | Dasatinib | BCR/ABL | MAPK/nRTK | Inf | 0.5642 | 0.1850 | 0.0047 | 1.3689 | 0.14044 | 0.98104 |
| SUM159PT | Etoposide | Topo II | Chemotherapy | 0.41904 | -0.1489 | 0.3736 | 0.1389 | 1.7468 | 0.47824 | 0.99862 |
| SUM159PT | Trametinib | MEK | MAPK/nRTK | 0.0055877 | 0.2792 | 0.4613 | 0.0039 | 0.9923 | 0.0023029 | 0.99862 |
| SUM159PT | Taxol | Chemo | Chemotherapy | 0.0047473 | -0.1485 | 0.6380 | 0.2976 | 2.2238 | 0.0052544 | 0.99906 |
| SUM159PT | Doxorubicin | Chemo | Chemotherapy | 0.019121 | -0.2740 | 0.6068 | 0.2965 | 1.5857 | 0.022541 | 0.98806 |
| SUM159PT | Topotecan | Topo I | Chemotherapy | 0.019593 | -0.3284 | 0.7927 | 0.3329 | 1.4860 | 0.025267 | 0.97848 |
| SUM159PT | Saracatinib | SRC | MAPK/nRTK | 13.9057 | 0.5624 | 0.0724 | -0.0011 | 0.9804 | 8.3037 | 0.99931 |
| SUM159PT | Volasertib | PLK | Cell cycle | 0.024832 | 0.0468 | 0.3873 | 0.1208 | 3.5660 | 0.024055 | 0.99966 |
| SUM159PT | AZD7762 | CHK1/2 | Cell cycle | 0.81589 | -0.1124 | 0.2697 | 0.0926 | 1.5031 | 0.93462 | 0.99443 |
| SUM159PT | Dinaciclib | pan CDK | Cell cycle | 0.016967 | -0.0646 | 0.4536 | 0.1030 | 5.0000 | 0.017277 | 0.99948 |
| SUM159PT | Abemaciclib | CDK4/6 | Cell cycle | 0.28398 | -0.4677 | 0.4585 | 0.1015 | 0.4799 | 2.802 | 0.95259 |
| SUM159PT | Palbociclib | CDK4/6 | Cell cycle | 1.1058 | 0.3876 | 0.1990 | -0.0006 | 0.6326 | 0.40763 | 0.99661 |
| SUM159PT | Cisplatin | Chemo | Chemotherapy | 5.2539 | 0.1742 | 0.1149 | 0.0416 | 1.1412 | 13.758 | 0.99717 |
| SUM159PT | ABT-737 | Bcl2/XL | Misc | 14.892 | 0.6822 | 0.0239 | 0.0074 | 1.9362 | 14.743 | 0.99356 |
| SUM159PT | Luminespib | HSP90 | Misc | 0.0063084 | -0.0476 | 0.5743 | 0.2156 | 4.5596 | 0.0064127 | 0.9997 |
| SUM159PT | Vorinostat | HDAC | Misc | 1.9985 | 0.1195 | 0.1810 | 0.0216 | 1.3229 | 1.9352 | 0.99956 |