Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1806 AZD7762
10.0
CHK1/2
Cell cycle
 -0.4822 0.71750
HCC1806 Volasertib
0.0001
PLK
Cell cycle
 1.0118 0.00039
HCC1806 Volasertib
0.00031623
PLK
Cell cycle
 1.0541 -0.00368
HCC1806 Volasertib
0.001
PLK
Cell cycle
 0.9852 0.00748
HCC1806 Volasertib
0.0031623
PLK
Cell cycle
 0.3271 0.18652
HCC1806 Volasertib
0.01
PLK
Cell cycle
 -0.1860 0.51709
HCC1806 Volasertib
0.031623
PLK
Cell cycle
 -0.1662 0.51589
HCC1806 Volasertib
0.1
PLK
Cell cycle
 -0.1298 0.49534
HCC1806 Volasertib
0.31623
PLK
Cell cycle
 -0.1323 0.48287
HCC1806 Volasertib
1.0
PLK
Cell cycle
 -0.1276 0.45270
HCC1806 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0433 -0.00285
HCC1806 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0550 -0.01089
HCC1806 Dinaciclib
0.001
pan CDK
Cell cycle
 1.0024 0.00199
HCC1806 Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9967 0.00059
HCC1806 Dinaciclib
0.01
pan CDK
Cell cycle
 0.7679 0.03547
HCC1806 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.3312 0.59546
HCC1806 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.4756 0.73826
HCC1806 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.4585 0.72620
HCC1806 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.4497 0.71822
HCC1806 AZD7762
0.1
CHK1/2
Cell cycle
 -0.2483 0.52952
HCC1806 Palbociclib
0.001
CDK4/6
Cell cycle
 1.0121 0.00165
HCC1806 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.2887 0.58594
HCC1806 Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9535 -0.00157
Hs 578T Abemaciclib
0.1
CDK4/6
Cell cycle
 0.4237 0.07522
Hs 578T Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.5384 0.04538