Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
---|---|---|---|---|---|---|
BT-20 | Cisplatin | 0.1 | Chemo | Chemotherapy | 0.9474 | 0.00664 |
BT-20 | Cisplatin | 0.31623 | Chemo | Chemotherapy | 0.7633 | 0.01654 |
BT-20 | Cisplatin | 3.1623 | Chemo | Chemotherapy | 0.0662 | 0.10679 |
BT-20 | Cisplatin | 10.0 | Chemo | Chemotherapy | -0.3367 | 0.52833 |
BT-20 | Doxorubicin | 0.01 | Chemo | Chemotherapy | 0.4333 | 0.12869 |
BT-20 | Doxorubicin | 0.031623 | Chemo | Chemotherapy | -0.1440 | 0.31126 |
BT-20 | Doxorubicin | 0.31623 | Chemo | Chemotherapy | -0.3158 | 0.50771 |
BT-20 | Doxorubicin | 1.0 | Chemo | Chemotherapy | -0.4813 | 0.65568 |
BT-20 | Taxol | 0.00031623 | Chemo | Chemotherapy | 1.0128 | 0.00568 |
BT-20 | Taxol | 0.001 | Chemo | Chemotherapy | 0.8429 | 0.05831 |
BT-20 | Taxol | 0.01 | Chemo | Chemotherapy | -0.4404 | 0.67612 |
BT-20 | Taxol | 0.031623 | Chemo | Chemotherapy | -0.5117 | 0.70834 |
BT-20 | Abemaciclib | 0.001 | CDK4/6 | Cell cycle | 0.9370 | -0.00149 |
BT-20 | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 0.8833 | -0.00527 |
BT-20 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.4936 | -0.00426 |
BT-20 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.3565 | 0.00950 |
BT-20 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | 0.1622 | 0.01068 |
BT-20 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.2160 | 0.37259 |
BT-20 | Palbociclib | 0.001 | CDK4/6 | Cell cycle | 1.0987 | -0.00539 |
BT-20 | Palbociclib | 0.0031623 | CDK4/6 | Cell cycle | 0.9966 | 0.00011 |
BT-20 | Palbociclib | 0.31623 | CDK4/6 | Cell cycle | 0.2359 | 0.04751 |
BT-20 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.2044 | 0.04646 |
BT-20 | AZD7762 | 0.001 | CHK1/2 | Cell cycle | 1.1198 | -0.00253 |
BT-20 | Topotecan | 0.01 | Topo I | Chemotherapy | 0.5944 | 0.03501 |
BT-20 | Topotecan | 0.0033333 | Topo I | Chemotherapy | 0.8298 | 0.01267 |