Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D Ceritinib
0.0031623
ALK
RTK
 1.0140 -0.00096
T47D Ceritinib
0.01
ALK
RTK
 1.0195 0.00391
T47D Ceritinib
0.1
ALK
RTK
 0.8770 0.00070
T47D Ceritinib
0.31623
ALK
RTK
 0.7724 0.00245
T47D Abemaciclib
0.001
CDK4/6
Cell cycle
 0.8683 -0.00073
T47D Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.6048 0.00282
T47D Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.1058 0.01541
T47D Abemaciclib
0.1
CDK4/6
Cell cycle
 0.1609 0.00818
T47D Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.0494 0.06623
T47D Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.0412 0.10529
T47D Palbociclib
0.001
CDK4/6
Cell cycle
 1.0459 -0.00050
T47D Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.0099 0.00184
T47D Palbociclib
0.31623
CDK4/6
Cell cycle
 0.1804 0.01826
T47D Palbociclib
1.0
CDK4/6
Cell cycle
 0.1166 0.01548
T47D AZD7762
0.001
CHK1/2
Cell cycle
 1.2145 -0.00469
T47D AZD7762
0.0031623
CHK1/2
Cell cycle
 1.2355 0.00015
T47D AZD7762
0.1
CHK1/2
Cell cycle
 1.2980 0.00257
T47D AZD7762
0.31623
CHK1/2
Cell cycle
 1.1810 0.00498
T47D AZD7762
3.1623
CHK1/2
Cell cycle
 0.2905 0.06193
T47D AZD7762
10.0
CHK1/2
Cell cycle
 -0.0573 0.09637
T47D Volasertib
0.01
PLK
Cell cycle
 0.8485 0.00521
T47D Volasertib
0.031623
PLK
Cell cycle
 0.5177 0.04885
T47D Volasertib
0.31623
PLK
Cell cycle
 -0.0906 0.16641
T47D Neratinib
0.031623
EGFR/HER2
RTK
 0.7538 0.00426
T47D Neratinib
0.01
EGFR/HER2
RTK
 0.8992 0.00476