Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HME1 Volasertib
0.1
PLK
Cell cycle
 0.0056 0.27294
HME1 Volasertib
0.31623
PLK
Cell cycle
 0.0006 0.29205
HME1 Volasertib
1.0
PLK
Cell cycle
 -0.0817 0.35780
HME1 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0822 0.00062
HME1 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0841 -0.00221
HME1 Dinaciclib
0.001
pan CDK
Cell cycle
 1.1064 0.00103
HME1 Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.0857 0.00459
HME1 Dinaciclib
0.01
pan CDK
Cell cycle
 0.7430 0.02978
HME1 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.2762 0.57032
HME1 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.2822 0.56449
HME1 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.2779 0.54016
HME1 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.2848 0.50971
HME1 Cisplatin
0.0010833
Chemo
Chemotherapy
 1.0148 0.00239
HME1 Cisplatin
0.0033333
Chemo
Chemotherapy
 0.9629 -0.00204
HME1 Cisplatin
0.01
Chemo
Chemotherapy
 0.9154 -0.00233
HME1 Cisplatin
0.031667
Chemo
Chemotherapy
 0.9578 0.00018
HME1 Cisplatin
0.1
Chemo
Chemotherapy
 0.9267 -0.00353
HME1 Cisplatin
0.31623
Chemo
Chemotherapy
 0.8040 -0.00263
HME1 Cisplatin
1.0
Chemo
Chemotherapy
 0.5209 0.03314
HME1 Cisplatin
3.1623
Chemo
Chemotherapy
 0.1561 0.16070
HME1 Cisplatin
10.0
Chemo
Chemotherapy
 -0.2180 0.51805
HME1 Doxorubicin
0.00031623
Chemo
Chemotherapy
 0.8166 0.01460
HME1 Doxorubicin
0.001
Chemo
Chemotherapy
 0.9126 0.00732
HME1 Doxorubicin
0.0031623
Chemo
Chemotherapy
 0.7219 0.02640
HME1 Doxorubicin
0.01
Chemo
Chemotherapy
 0.1014 0.14556