Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
CAL-120 Trametinib
0.31623
MEK
MAPK/nRTK
 0.4153 0.06473
CAL-120 Trametinib
1.0
MEK
MAPK/nRTK
 0.4370 0.06675
CAL-120 Saracatinib
0.001
SRC
MAPK/nRTK
 0.9767 0.00131
CAL-120 Saracatinib
0.0031623
SRC
MAPK/nRTK
 0.9687 0.00278
CAL-120 Saracatinib
0.01
SRC
MAPK/nRTK
 0.9773 0.00301
CAL-120 Saracatinib
0.031623
SRC
MAPK/nRTK
 0.8647 -0.00231
CAL-120 Saracatinib
0.1
SRC
MAPK/nRTK
 0.8564 0.00086
CAL-120 Saracatinib
0.31623
SRC
MAPK/nRTK
 0.7758 0.00298
CAL-120 Saracatinib
1.0
SRC
MAPK/nRTK
 0.7413 0.00516
CAL-120 Saracatinib
3.1623
SRC
MAPK/nRTK
 0.6806 0.02356
CAL-120 Saracatinib
10.0
SRC
MAPK/nRTK
 0.5261 0.03319
CAL-120 ABT-737
0.001
Bcl2/XL
Misc
 1.0022 -0.00028
CAL-120 ABT-737
0.0031623
Bcl2/XL
Misc
 1.0233 -0.00607
CAL-120 ABT-737
0.01
Bcl2/XL
Misc
 1.0016 0.00083
CAL-120 ABT-737
0.031623
Bcl2/XL
Misc
 1.0430 0.00331
CAL-120 ABT-737
0.1
Bcl2/XL
Misc
 1.0305 0.00949
CAL-120 ABT-737
0.31623
Bcl2/XL
Misc
 0.9463 0.01982
CAL-120 ABT-737
1.0
Bcl2/XL
Misc
 0.8098 0.07286
CAL-120 ABT-737
3.1623
Bcl2/XL
Misc
 0.2626 0.28822
CAL-120 ABT-737
10.0
Bcl2/XL
Misc
 -0.4339 0.60838
CAL-120 Vorinostat
0.001
HDAC
Misc
 1.0255 -0.00533
CAL-120 Vorinostat
0.0031623
HDAC
Misc
 0.9781 -0.00205
CAL-120 Vorinostat
0.01
HDAC
Misc
 1.0242 0.00225
CAL-120 Vorinostat
0.031623
HDAC
Misc
 1.0296 0.00795
CAL-120 Vorinostat
0.1
HDAC
Misc
 0.9757 0.00539