Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC38 Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9840 0.00813
HCC38 Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 1.0279 -0.01465
HCC38 Pictilisib
0.01
pan PI3K
PI3K/mTOR
 1.0095 -0.00095
HCC38 Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.9546 -0.00404
HCC38 Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.9518 -0.00154
HCC38 Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.8842 0.00275
HCC38 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.8373 0.01267
HCC38 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.7185 0.01063
HCC38 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 0.3569 0.04678
HCC38 Ceritinib
0.001
ALK
RTK
 0.9819 0.00099
HCC38 Ceritinib
0.0031623
ALK
RTK
 1.0734 0.01015
HCC38 Ceritinib
0.01
ALK
RTK
 1.0960 -0.00029
HCC38 Ceritinib
0.031623
ALK
RTK
 1.0629 0.00190
HCC38 Ceritinib
0.1
ALK
RTK
 0.9968 -0.00341
HCC38 Ceritinib
0.31623
ALK
RTK
 0.9475 0.00674
HCC38 Ceritinib
1.0
ALK
RTK
 0.8629 0.02536
HCC38 Ceritinib
3.1623
ALK
RTK
 0.0064 0.23382
HCC38 Ceritinib
10.0
ALK
RTK
 -0.4039 0.51925
HCC38 Neratinib
0.00031623
EGFR/HER2
RTK
 1.0263 0.01874
HCC38 Neratinib
0.001
EGFR/HER2
RTK
 1.0291 0.00684
HCC38 Neratinib
0.0031623
EGFR/HER2
RTK
 0.9907 0.01205
HCC38 Neratinib
0.01
EGFR/HER2
RTK
 0.9343 0.00755
HCC38 Neratinib
0.031623
EGFR/HER2
RTK
 0.8742 0.01311
HCC38 Neratinib
0.1
EGFR/HER2
RTK
 0.9280 -0.00203
HCC38 Neratinib
0.31623
EGFR/HER2
RTK
 0.8367 0.00913