Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC38 TGX221
0.1
PI3Kb
PI3K/mTOR
 1.0321 0.00924
HCC38 TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.0777 -0.01157
HCC38 TGX221
1.0
PI3Kb
PI3K/mTOR
 1.0647 0.00582
HCC38 TGX221
3.1623
PI3Kb
PI3K/mTOR
 0.9814 -0.01191
HCC38 TGX221
10.0
PI3Kb
PI3K/mTOR
 0.9515 0.00692
HCC38 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0020 0.01786
HCC38 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9876 0.00611
HCC38 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.9777 0.00889
HCC38 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.7194 0.01754
HCC38 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.4795 0.04461
HCC38 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.2408 0.05646
HCC38 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 -0.0069 0.14496
HCC38 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 -0.1000 0.21209
HCC38 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.2107 0.32621
HCC38 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.5533 0.02762
HCC38 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.5226 0.00456
HCC38 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.5465 0.02214
HCC38 Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.4847 0.00730
HCC38 Everolimus
0.1
mTOR1
PI3K/mTOR
 0.4867 0.02307
HCC38 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.5368 0.00380
HCC38 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.5124 0.01018
HCC38 Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.5046 -0.00472
HCC38 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.4735 0.03177
HCC38 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 1.0390 -0.00115
HCC38 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9708 0.01472