Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SK-BR-3 AZD7762
0.01
CHK1/2
Cell cycle
 0.9248 0.08349
SK-BR-3 AZD7762
0.1
CHK1/2
Cell cycle
 -0.3118 0.41140
SK-BR-3 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.3571 0.41177
HCC1806 Volasertib
0.001
PLK
Cell cycle
 0.9852 0.00748
MDA-MB-231 Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0771 0.00134
SK-BR-3 Volasertib
0.0031623
PLK
Cell cycle
 0.9176 0.02544
SK-BR-3 Volasertib
0.001
PLK
Cell cycle
 1.1369 -0.00599
SK-BR-3 Volasertib
0.1
PLK
Cell cycle
 -0.2755 0.51415
SK-BR-3 Volasertib
0.031623
PLK
Cell cycle
 -0.2769 0.50115
SK-BR-3 Volasertib
0.31623
PLK
Cell cycle
 -0.2822 0.51136
SK-BR-3 Volasertib
1.0
PLK
Cell cycle
 -0.3494 0.53084
HCC1806 Palbociclib
0.1
CDK4/6
Cell cycle
 0.7323 0.02268
MDA-MB-231 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.8583 0.00282
MDA-MB-231 Abemaciclib
0.001
CDK4/6
Cell cycle
 0.9195 0.00637
SK-BR-3 Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9472 0.01034
MDA-MB-231 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.4981 0.00329
MDA-MB-231 Abemaciclib
0.01
CDK4/6
Cell cycle
 0.7012 -0.00059
MDA-MB-231 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.2911 0.03747
MDA-MB-231 Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.1512 0.05085
HCC1806 Volasertib
0.0031623
PLK
Cell cycle
 0.3271 0.18652
MDA-MB-231 Palbociclib
0.001
CDK4/6
Cell cycle
 0.9933 0.00405
MDA-MB-231 Palbociclib
0.01
CDK4/6
Cell cycle
 0.8221 -0.00579
MDA-MB-231 Palbociclib
0.031623
CDK4/6
Cell cycle
 0.6564 -0.00354
PDX1328 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.1548 0.02050
PDX1328 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.1637 0.02997