Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
Hs 578T Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.5825 0.84364
Hs 578T Palbociclib
0.001
CDK4/6
Cell cycle
 0.9864 0.00720
Hs 578T Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0302 -0.00544
HCC1806 Volasertib
0.31623
PLK
Cell cycle
 -0.1323 0.48287
Hs 578T Palbociclib
0.31623
CDK4/6
Cell cycle
 0.4560 0.05357
Hs 578T Palbociclib
0.1
CDK4/6
Cell cycle
 0.5601 0.04580
Hs 578T Palbociclib
0.031623
CDK4/6
Cell cycle
 0.6661 0.01800
Hs 578T AZD7762
0.0031623
CHK1/2
Cell cycle
 1.0447 0.01452
Hs 578T Palbociclib
1.0
CDK4/6
Cell cycle
 0.4135 0.07460
Hs 578T AZD7762
0.001
CHK1/2
Cell cycle
 1.0689 0.00507
Hs 578T Palbociclib
3.1623
CDK4/6
Cell cycle
 0.3049 0.11532
HCC1806 Volasertib
1.0
PLK
Cell cycle
 -0.1276 0.45270
Hs 578T AZD7762
0.31623
CHK1/2
Cell cycle
 -0.1923 0.55069
HCC1806 Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.4440 0.69010
Hs 578T Volasertib
0.00031623
PLK
Cell cycle
 0.9663 0.00418
HCC1806 Palbociclib
3.1623
CDK4/6
Cell cycle
 0.7848 0.00614
Hs 578T AZD7762
1.0
CHK1/2
Cell cycle
 -0.1765 0.54208
Hs 578T AZD7762
10.0
CHK1/2
Cell cycle
 -0.5983 0.86377
Hs 578T AZD7762
3.1623
CHK1/2
Cell cycle
 -0.3399 0.65876
HCC1806 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0433 -0.00285
Hs 578T Volasertib
0.01
PLK
Cell cycle
 -0.2484 0.51390
Hs 578T Volasertib
0.0031623
PLK
Cell cycle
 0.2994 0.18889
Hs 578T Volasertib
0.001
PLK
Cell cycle
 0.9608 0.01359
BT-20 Volasertib
0.001
PLK
Cell cycle
 1.0085 0.00742
BT-20 Volasertib
0.00031623
PLK
Cell cycle
 1.0308 0.00572