Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SK-BR-3 Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9472 0.01034
MCF 10A Volasertib
0.31623
PLK
Cell cycle
 -0.0849 0.41479
MCF 10A Volasertib
0.1
PLK
Cell cycle
 -0.0850 0.41060
SK-BR-3 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.5830 0.57124
HCC1806 Volasertib
0.01
PLK
Cell cycle
 -0.1860 0.51709
Hs 578T AZD7762
0.001
CHK1/2
Cell cycle
 1.0689 0.00507
HCC1806 Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.1267 0.14911
Hs 578T Palbociclib
0.031623
CDK4/6
Cell cycle
 0.6661 0.01800
HCC1806 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.7287 0.01539
Hs 578T Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.2917 0.09522
Hs 578T Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9286 0.00241
Hs 578T Palbociclib
0.001
CDK4/6
Cell cycle
 0.9864 0.00720
HCC1806 Volasertib
0.031623
PLK
Cell cycle
 -0.1662 0.51589
Hs 578T Palbociclib
0.31623
CDK4/6
Cell cycle
 0.4560 0.05357
Hs 578T Palbociclib
0.1
CDK4/6
Cell cycle
 0.5601 0.04580
Hs 578T Abemaciclib
0.1
CDK4/6
Cell cycle
 0.4237 0.07522
HCC1806 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.7658 0.01650
Hs 578T Abemaciclib
0.001
CDK4/6
Cell cycle
 0.9336 0.00408
Hs 578T Abemaciclib
0.01
CDK4/6
Cell cycle
 0.7172 0.02597
Hs 578T Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.7910 0.00854
HCC1806 Volasertib
0.1
PLK
Cell cycle
 -0.1298 0.49534
Hs 578T Abemaciclib
3.1623
CDK4/6
Cell cycle
 -0.2382 0.50027
Hs 578T Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.5825 0.84364
BT-20 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.3565 0.00950
BT-20 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.4936 -0.00426