Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-231 AZD7762
10.0
CHK1/2
Cell cycle
 -0.4632 0.68964
HCC1806 Palbociclib
0.031623
CDK4/6
Cell cycle
 0.8470 0.00941
MCF 10A Palbociclib
0.01
CDK4/6
Cell cycle
 0.9387 -0.00416
MDA-MB-231 Volasertib
0.0031623
PLK
Cell cycle
 0.7618 0.02847
MDA-MB-231 Volasertib
0.01
PLK
Cell cycle
 0.0321 0.22457
HCC1806 Volasertib
0.00031623
PLK
Cell cycle
 1.0541 -0.00368
MDA-MB-231 Volasertib
1.0
PLK
Cell cycle
 -0.0186 0.13531
MDA-MB-231 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0243 0.00209
MDA-MB-231 Dinaciclib
0.001
pan CDK
Cell cycle
 0.9617 0.00541
MDA-MB-231 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.2901 0.46501
MDA-MB-231 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.3532 0.56698
MDA-MB-231 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.4203 0.61381
SK-BR-3 Abemaciclib
0.001
CDK4/6
Cell cycle
 0.8713 0.00683
HCC1806 Volasertib
0.001
PLK
Cell cycle
 0.9852 0.00748
MCF 10A Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9789 -0.00222
SK-BR-3 Abemaciclib
1.0
CDK4/6
Cell cycle
 0.2397 0.06137
SK-BR-3 Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.2641 0.04005
HCC1806 Palbociclib
0.1
CDK4/6
Cell cycle
 0.7323 0.02268
MCF 10A Abemaciclib
1.0
CDK4/6
Cell cycle
 0.3536 -0.00320
MCF 10A Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.5264 -0.00795
SK-BR-3 Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9382 0.00629
HCC1806 Volasertib
0.0031623
PLK
Cell cycle
 0.3271 0.18652
MCF 10A Palbociclib
0.001
CDK4/6
Cell cycle
 1.0040 0.00068
SK-BR-3 AZD7762
1.0
CHK1/2
Cell cycle
 -0.4093 0.41557
SK-BR-3 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.3571 0.41177